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- W4367301816 endingPage "156206" @default.
- W4367301816 startingPage "156206" @default.
- W4367301816 abstract "Inflammation and oxidative stress play pivotal roles in pathogenesis of many diseases including cancer, type 2 diabetes, cardiovascular disease, atherosclerosis, neurological diseases, and inflammatory diseases such as inflammatory bowel disease (IBD). Inflammatory mediators such as interleukins (ILs), interferons (INF-s), and tumor necrosis factor (TNF)-α are related to an extended chance of inflammatory diseases initiation or progression due to the over expression of the nuclear factor Kappa B (NF-κB), signal transducer of activators of transcription (STAT), nod‐like receptor family protein 3 (NLRP), toll-like receptors (TLR), mitogen‐activated protein kinase (MAPK), and mammalian target of rapamycin (mTOR) pathways. These pathways are completely interconnected. The indoleamine 2,3 dioxygenase (IDO) subset of the kynurenine (KYN) (IDO/KYN), is a metabolic inflammatory pathway involved in production of nicotinamide adenine dinucleotide (NAD + ). It has been shown that IDO/KYN actively participates in inflammatory processes and can increase the secretion of cytokines that provoke inflammatory diseases. Data were extracted from clinical and animal studies published in English between 1990-April 2022, which were collected from PubMed, Google Scholar, Scopus, and Cochrane library. IDO/KYN is completely associated with inflammatory-related pathways, thus leading to the production of cytokines such as TNF-α, IL-1β, and IL-6, and ultimately development and progression of various inflammatory disorders. Inhibition of the IDO/KYN pathway might be a novel therapeutic option for inflammatory diseases. Herein, we gathered data on probable interactions of the IDO/KYN pathway with induction of some inflammatory diseases." @default.
- W4367301816 created "2023-04-29" @default.
- W4367301816 creator A5025708210 @default.
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- W4367301816 creator A5062575496 @default.
- W4367301816 creator A5080943824 @default.
- W4367301816 creator A5084340806 @default.
- W4367301816 date "2023-06-01" @default.
- W4367301816 modified "2023-10-03" @default.
- W4367301816 title "IDO/Kynurenine; novel insight for treatment of inflammatory diseases" @default.
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