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- W4367302542 abstract "Abstract In the Drosophila germline stem cell system, maintenance of the stem cell pool requires “dedifferentiation”, in which differentiating cells reattach to the niche and reacquire stem cell properties. However, the mechanism of dedifferentiation remains poorly understood. Here, using long-term live imaging, we show that dedifferentiated cells immediately re-enter mitosis with correct spindle orientation after reattachment to the niche. Analysis of cell cycle markers revealed that these dedifferentiating cells are all in G2 phase. In addition, we found that the observed G2 block during dedifferentiation likely corresponds to a centrosome orientation checkpoint (COC), a previously reported polarity checkpoint. We show that re-activation of a COC is likely required for the dedifferentiation thus ensuring asymmetric division even in dedifferentiated stem cells. Taken together, our study demonstrates the remarkable ability of dedifferentiating cells to reacquire the ability to divide asymmetrically." @default.
- W4367302542 created "2023-04-29" @default.
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- W4367302542 date "2023-04-28" @default.
- W4367302542 modified "2023-09-24" @default.
- W4367302542 title "Dedifferentiating germ cells regain stem-cell specific polarity checkpoint prior to niche reentry" @default.
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- W4367302542 doi "https://doi.org/10.1101/2023.04.26.538507" @default.
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