FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367302585> ?p ?o ?g. }

• W4367302585 abstract "<h3>Objective:</h3> To elucidate the role of inflammatory cytokines in Acute Ischemic Stroke patients <h3>Background:</h3> Acute ischemic stroke (AIS) is one of the leading causes of mortality and long-term disability. Ischemic changes results in inflammatory process characterized by various molecules and cytokines. There is limited data on the early changes and interaction in these cytokines. The aim of this study is to characterize the inflammatory response and explore the interaction of multiple cytokines and molecules among acute ischemic stroke (AIS) patients. <h3>Design/Methods:</h3> This is a prospective study of AIS patients presented to a tertiary care hospital within 24 hours from the symptom onset. Patients with prior history of stroke, autoimmune diseases, and neurodegenerative diseases were excluded. Plasma samples were collected on admission and at 24 hours. Cytokines and molecules were analyzed using enzyme-linked immunosorbent assay (ELISA). R-software was used for evaluating the differences among the molecules. <h3>Results:</h3> A total of 100 patients (males: 54; females: 46) from Caucasian, Hispanic, and Native American descent were included. Cytokine quantification observed a significant increase in PDGF, MPO, and MMP-9 among cases as compared to the controls at admission and 24 hours. Moreover, the levels of IL-33, IL-36, PDGF, MMP-9, and TNF-α decreases over time. Furthermore, IL-1 and IL-23 were negatively corelated with NIHSS, while the levels of IL-6 were positively corelated with infarct volume. <h3>Conclusions:</h3> Our results characterize the trends in inflammatory molecules over time and their correlation with stroke severity. These observations help to better understand the inflammatory response and identify molecular biomarkers and relevant targets for subsequent modulating therapeutic interventions in AIS patients. <b>Disclosure:</b> Dr. Farooqui has nothing to disclose. sajid suriya has nothing to disclose. Dr. Ikram has nothing to disclose. Dr. Qaryouti has nothing to disclose. Dr. Quadri has nothing to disclose. The institution of Dr. Paul has received research support from NIH/NINDS. Dr. Zafar has nothing to disclose." @default.
• W4367302585 created "2023-04-29" @default.
• W4367302585 creator A5008384414 @default.
• W4367302585 creator A5047157702 @default.
• W4367302585 creator A5048914085 @default.
• W4367302585 creator A5058015360 @default.
• W4367302585 creator A5060065054 @default.
• W4367302585 creator A5067401387 @default.
• W4367302585 creator A5078176929 @default.
• W4367302585 date "2023-04-25" @default.
• W4367302585 modified "2023-10-16" @default.
• W4367302585 title "Inflammatory Markers in Patients with Acute Ischemic Stroke (P3-5.003)" @default.
• W4367302585 doi "https://doi.org/10.1212/wnl.0000000000203648" @default.
• W4367302585 hasPublicationYear "2023" @default.
• W4367302585 type Work @default.
• W4367302585 citedByCount "0" @default.
• W4367302585 crossrefType "proceedings-article" @default.
• W4367302585 hasAuthorship W4367302585A5008384414 @default.
• W4367302585 hasAuthorship W4367302585A5047157702 @default.
• W4367302585 hasAuthorship W4367302585A5048914085 @default.
• W4367302585 hasAuthorship W4367302585A5058015360 @default.
• W4367302585 hasAuthorship W4367302585A5060065054 @default.
• W4367302585 hasAuthorship W4367302585A5067401387 @default.
• W4367302585 hasAuthorship W4367302585A5078176929 @default.
• W4367302585 hasConcept C126322002 @default.
• W4367302585 hasConcept C127413603 @default.
• W4367302585 hasConcept C164027704 @default.
• W4367302585 hasConcept C203014093 @default.
• W4367302585 hasConcept C2776914184 @default.
• W4367302585 hasConcept C2778690821 @default.
• W4367302585 hasConcept C2780645631 @default.
• W4367302585 hasConcept C3020199598 @default.
• W4367302585 hasConcept C541997718 @default.
• W4367302585 hasConcept C71924100 @default.
• W4367302585 hasConcept C78519656 @default.
• W4367302585 hasConceptScore W4367302585C126322002 @default.
• W4367302585 hasConceptScore W4367302585C127413603 @default.
• W4367302585 hasConceptScore W4367302585C164027704 @default.
• W4367302585 hasConceptScore W4367302585C203014093 @default.
• W4367302585 hasConceptScore W4367302585C2776914184 @default.
• W4367302585 hasConceptScore W4367302585C2778690821 @default.
• W4367302585 hasConceptScore W4367302585C2780645631 @default.
• W4367302585 hasConceptScore W4367302585C3020199598 @default.
• W4367302585 hasConceptScore W4367302585C541997718 @default.
• W4367302585 hasConceptScore W4367302585C71924100 @default.
• W4367302585 hasConceptScore W4367302585C78519656 @default.
• W4367302585 hasLocation W43673025851 @default.
• W4367302585 hasOpenAccess W4367302585 @default.
• W4367302585 hasPrimaryLocation W43673025851 @default.
• W4367302585 hasRelatedWork W1984501713 @default.
• W4367302585 hasRelatedWork W1995850895 @default.
• W4367302585 hasRelatedWork W2011513035 @default.
• W4367302585 hasRelatedWork W2070650056 @default.
• W4367302585 hasRelatedWork W2120522249 @default.
• W4367302585 hasRelatedWork W2165578318 @default.
• W4367302585 hasRelatedWork W2170299167 @default.
• W4367302585 hasRelatedWork W2313033156 @default.
• W4367302585 hasRelatedWork W2378869413 @default.
• W4367302585 hasRelatedWork W2408793777 @default.
• W4367302585 isParatext "false" @default.
• W4367302585 isRetracted "false" @default.
• W4367302585 workType "article" @default.