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- W4367302657 abstract "Abstract In this regard, we developed vitexin (Vi)-loaded D- ɑ -tocopherol polyethylene glycol succinate, polyvinylpyrrolidone K30 and sodium cholate mixed micelles (Vi-MMs) mainly for improving oral bioavailability and enhancing anti-osteoporotic effect of Vi. Thin layer dispersion method was employed to prepare Vi-MMs, and then the optimal prescription was optimized by the orthogonal design-response surface method, wherein encapsulation efficiency (EE) was used as optimizing index. The physical properties of Vi-MMs such as appearance morphology, particle size, and zeta potential were also characterized. We further analyzed the in-vitro release of Vi and Vi-MMs in three media and investigated the pharmacokinetics of Vi and Vi-MMs in rats. Anti-osteoporotic activity of Vi and Vi-MMs was assessed by establishing a zebrafish osteoporosis model with prednisone. Drug loading, EE, particle size and zeta potential of the optimized Vi-MMs were 8.58 ± 0.13%, 93.86 ± 1.79%, 20.41 ± 0.64 nm and −10 ± 0.56 mV, respectively. The optimized Vi-MMs were shaped spherically as exhibited by transmission electron microscopic technique, with evident core shell nano-structure, well dispersed. In all three media, the release rate of Vi-MMs was significantly higher than that of free Vi. The oral bioavailability of Vi-MMs was increased by 5.6-fold compared to free Vi. In addition, alleviation of prednisone induced osteoporosis in zebrafish by Vi-MMs further demonstrated good anti-osteoporotic effect. In summary, Vi-MMs exhibited enhanced bioavailability and anti-osteoporotic effect, which is expected to be potential nanocarrier for Vi applications in drug development." @default.
- W4367302657 created "2023-04-29" @default.
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- W4367302657 date "2023-05-15" @default.
- W4367302657 modified "2023-09-28" @default.
- W4367302657 title "Vitexin loaded mixed polymeric micelles: preparation, optimization, evaluation and anti-osteoporotic effect" @default.
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- W4367302657 doi "https://doi.org/10.1088/1748-605x/acd15b" @default.
- W4367302657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37116506" @default.
- W4367302657 hasPublicationYear "2023" @default.
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