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• W4367303558 abstract "<h3>Objective:</h3> We aimed to investigate whether polysomnographic (PSG) sleep parameters are associated with neuroimaging biomarkers of cerebrovascular disease in older adults. <h3>Background:</h3> White matter abnormalities are reflective of vascular contributions to cognitive impairment and dementia (VCID) in the elderly, but their relationship with sleep remains unclear. <h3>Design/Methods:</h3> From the population-based Mayo Clinic Study of Aging, we identified 140 non-demented participants who underwent at least one brain MRI and a split-night PSG. We quantified two VCID biomarkers - white matter hyperintensities (WMH) from FLAIR-MRI (n=140) and fraction anisotropy of the genu of the corpus callosum (genu FA) from diffusion MRI (n=103). For this cross-sectional analysis, we fit linear models to assess associations between diagnostic PSG parameters (N1%, N3%, mean oxyhemoglobin saturation, and log of AHI) and VCID biomarkers (log of WMH and log of genu FA), respectively, while adjusting for age (at MRI), sex, APOE4 status, composite cardiovascular and metabolic conditions (CMC) score, REM%, supine%, sleep duration (from diagnostic portion), and interval between MRI and PSG. <h3>Results:</h3> The absolute median [IQR] interval between MRI imaging and PSG was 1.74 [0.9 – 3.2] years. For every 10-point decrease in N3%, there was a 0.058 (95% CI 0.006 to 0.111, p=0.030) increase in the log of WMH and 0.006 decrease ([95% CI −0.012 to −0.0002], p=0.042) in the log of genu FA. Participants with severe sleep apnea had higher WMH burden when compared to those with mild disease, after matching for age, sex, and N3% (median [IQR] of 0.0073 [0.0044 – 0.0149] vs 0.0067 [0.0034 to 0.01], p=0.039). <h3>Conclusions:</h3> We found that reduced slow-wave sleep and severe sleep apnea were associated with higher burden of white matter abnormalities in predominantly cognitively unimpaired older adults, which contribute to greater risk of cognitive impairment, dementia, and stroke. Our study provides support for the links between sleep depth/fragmentation and intermittent hypoxia and VCID. <b>Disclosure:</b> The institution of Dr. Carvalho has received research support from NIH. Dr. McCarter has nothing to disclose. Dr. St. Louis has received publishing royalties from a publication relating to health care. Dr. St. Louis has received publishing royalties from a publication relating to health care. Scott Przybelski has nothing to disclose. Timothy Morgenthaler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Respicardia. The institution of Timothy Morgenthaler has received research support from AR Medical. Timothy Morgenthaler has received publishing royalties from a publication relating to health care. Dr. Boeve has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Rainwater Charitable Foundation. The institution of Dr. Boeve has received research support from Alector. The institution of Dr. Boeve has received research support from GE Healthcare. The institution of Dr. Boeve has received research support from Transposon. The institution of Dr. Boeve has received research support from Cognition Therapeutics. Dr. Boeve has received publishing royalties from a publication relating to health care. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Nestle. Dr. Petersen has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech, Inc.. Dr. Petersen has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche, Inc.. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer’s Disease Research Professorship of the Mayo Clinic. Dr. Graff-Radford has received personal compensation for serving as an employee of Mayo Clinic. Dr. Graff-Radford has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NINDS/NIH. Dr. Graff-Radford has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Academy of Neurology. The institution of Dr. Graff-Radford has received research support from NIH. Dr. Vemuri has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Miller Medical Communications Inc.. The institution of Dr. Vemuri has received research support from NIH." @default.
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• W4367303558 date "2023-04-25" @default.
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• W4367303558 title "Reduced Slow-Wave Sleep and Severe Sleep Apnea are Associated with Neuroimaging Biomarkers of Cerebrovascular Disease (S6.004)" @default.
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