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- W4367303886 abstract "<h3>Objective:</h3> Represent post-thrombolysis angioedema, a relatively common adverse effect seen after administration of alteplase for acute ischemic stroke. <h3>Background:</h3> r-TPA induced angioedema is a common clinical finding after medication infusion for acute stroke. The incidence of this complication ranges from 1.3–8% (3, 4). Prognosis is usually good; most patients have symptom resolution within 72 hours (5). <h3>Design/Methods:</h3> Literature review revealed how signs and symptoms of angioedema differ in presentation and severity. We gathered case reports from the last decade to identify the most common location of stroke, site of edema, treatment used and complications of angioedema. <h3>Results:</h3> Symptoms usually began within 150 minutes after initial infusion (mean 70 minutes) and usually presented with unilateral angioedema, contralaterally to the side of the stroke. Approximately 30% of the patients required mechanical ventilation; most were on treatment with ACE inhibitors. The authors usually treated patients with a combination of steroids, antihistamines, adrenalin, or Icatibant, with complete recovery within 24 to 48 hours. <h3>Conclusions:</h3> Patients treated with Icatibant improved within minutes and achieved full remission in the first three hours. We believe it may become the standard of care in patients presenting with this uncommon but potentially life-threatening complication. <b>Disclosure:</b> Dr. Ayala Alvarez has nothing to disclose. Dr. Roque Sanchez has nothing to disclose. Dr. Jimenez-Ruiz has nothing to disclose. Dr. GOMEZ FIGUEROA has nothing to disclose. Omar Cardenas-Sanchez has nothing to disclose. Dr. Ruiz-Sandoval has nothing to disclose." @default.
- W4367303886 created "2023-04-29" @default.
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- W4367303886 date "2023-04-25" @default.
- W4367303886 modified "2023-10-18" @default.
- W4367303886 title "Alteplase-induced facial orolingual angioedema (P12-5.012)" @default.
- W4367303886 doi "https://doi.org/10.1212/wnl.0000000000201994" @default.
- W4367303886 hasPublicationYear "2023" @default.
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