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• W4367304801 abstract "<h3>Objective:</h3> 1- To describe the prevalence of CI and cognitive profile of the PwMS cohort. 2- To compare the cognitive performance of PwMS in relation to Expanded Disability Status Scale (EDSS) and MS duration. <h3>Background:</h3> Cognitive impairment (CI) is a common symptom of multiple sclerosis, with a negative effect on patients’ daily lives. <h3>Design/Methods:</h3> Cross-sectional study. Measuring instruments: Clinical and cognitive variables were assessed (EDSS, Fatigue severity scale, Beck Depression Inventory, BICAMS battery, PASAT, verbal fluency, 7/24 test). CI was defined as impairment in ≥ 2 cognitive domains. Parametric and non-parametric statistics were used, p< 0.05 was considered significant. <h3>Results:</h3> 323 PwMS were recruited. Mean age: 40.71±12.89 years; mean education: 13.43±4.2 years; mean EDSS: 2.05±1.94 (median 2.5 IQR8) and stratified EDSS was 0–3:61.7%; 3.5–8:38.3%; mean MS duration: 8.51±8.29 years; female 62.8%; relapsing-remitting MS (RRMS) 91.6%. Objectives: 1)The prevalence of CI at inclusion study was 47.5%. The most affected cognitive domains were: attention and processing speed followed by verbal memory, verbal fluency and visual memory. 2)Patients with EDSS between 3.5–8 presented worse cognitive performance (p<0.05). The PwMS duration >20 years presented worse cognitive performance compared to those of ≤5 years (p<0.05). The group of >20 years presented worse performance than those of 6–10 years (p<0.05). In a multivariable logistic regression model, EDSS was an independent risk factor to reach CI when adjusted for potential confounders (adjusted Odds Ratio (OR) 1.43, 95% confidence interval (CI) 1.09–1.87, p=0.01). <h3>Conclusions:</h3> The prevalence of IC in our cohort was similar to previous reports. Disability (EDSS) was an independent predictor of CI <b>Disclosure:</b> Barbara Eizaguirre has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Sanofi Genzyme Argenina. Barbara Eizaguirre has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Roche Argentina. Barbara Eizaguirre has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Roche. Barbara Eizaguirre has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Merck. Miss Ciufia has nothing to disclose. SIlva Berenice has nothing to disclose. Orlando Garcea has nothing to disclose. Ricardo Alonso has nothing to disclose. Aldana Marinangeli has nothing to disclose." @default.
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• W4367304801 date "2023-04-25" @default.
• W4367304801 modified "2023-09-30" @default.
• W4367304801 title "EDSS and MS duration is associated with cognitive impairment in a large Argentinian cohort of patient with multiple sclerosis (P13-3.009)" @default.
• W4367304801 doi "https://doi.org/10.1212/wnl.0000000000203409" @default.
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