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- W4367304821 abstract "<h3>Objective:</h3> Importance of various investigations for diagnoses by exclusion and importance of starting treatment, which might be common for specific pathologies irrespective of different etiologies. (in a resource-limited environment) <h3>Background:</h3> There were two cases of adult women (Patient G and Patient V) residing in the same neighborhood. They presented with similar complaints of right-sided orbital pain, headache, and sixth cranial nerve palsy. <h3>Design/Methods:</h3> On individual evaluation, Patient G had prominent right-sided dull orbital pain for 3 weeks with right-sided headache and diplopia for 1 week. Examination showed ipsilateral sixth nerve paresis. Investigations like Complete Blood Count, Complete Metabolic Panel, Chest X-ray, ANA, CSF Analysis (including Adenosine deaminase), ESR, and CRP were negative. MRI showed a single hypointense extra-axial lesion in right anteromedial temporal region, anterolateral to ipsilateral cavernous sinus. The lesion appeared to partially encase right sixth cranial nerve and approaching right superior orbital fissure. Patient V had similar complaints of right-sided headache for 4 weeks and diplopia for 1 week. Examination showed complete paralysis of ipsilateral sixth nerve palsy. Similarly, investigations were negative (including serum ACE levels). MRI revealed a single extra-axial hypointense lesion along right medial temporal region along with partial invasion of ipsilateral cavernous sinus. Mild asymmetric thickening of right fifth and sixth cranial nerves was seen. <h3>Results:</h3> Investigations were necessary to rule out differential diagnoses like tuberculous meningoencephalitis, thyroid ophthalmopathy, and other infectious, autoimmune, or neoplastic etiologies. By diagnosis of exclusion, patient G was diagnosed with <b>Tolosa-Hunt syndrome</b>. Though biopsy results were unavailable for patient V, she was provisionally diagnosed with <b>Neurosarcoidosis</b>. Both were started on Corticosteroids. On respective follow-up visits, both patients reported significant improvement in their symptoms. This further solidified the respective diagnoses in these patients. <h3>Conclusions:</h3> In a resource-limited environment, response to treatment is as important as other investigations to diagnose rare diseases by exclusion. <b>Disclosure:</b> Mr. Shah has nothing to disclose." @default.
- W4367304821 created "2023-04-29" @default.
- W4367304821 creator A5040292071 @default.
- W4367304821 date "2023-04-25" @default.
- W4367304821 modified "2023-10-01" @default.
- W4367304821 title "Curious Cases of Painful Ophthalmoplegia (P1-9.012)" @default.
- W4367304821 doi "https://doi.org/10.1212/wnl.0000000000201916" @default.
- W4367304821 hasPublicationYear "2023" @default.
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