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• W4367304849 abstract "<h3>Objective:</h3> To explore the differences between age-related cognitive decline, in which ADL is relatively preserved, and Alzheimer9s disease (AD), in which independent living becomes difficult within a few years. <h3>Background:</h3> Japan is one of the countries with the highest population of healthy long-lived individuals in the world. There are more than 90,000 centenarians in Japan, some of whom maintain relatively good cognitive function beyond age of 100. Studies of cognitive function in centenarians are considered important for elucidating the mechanism of resistance to the onset of dementia. <h3>Design/Methods:</h3> Among 1,017 centenarians, we examined the correlation between MMSE and age in 638 subjects with MMSE assessed fully. Various factors, including APOEɛ4 positivity, were compared between the centenarians (638 subjects) and the AD group (223 subjects) attending the memory clinic. In addition, the MMSE sub-items were examined to find out differences in the pattern of decline in the cognitive function between the centenarian group and the AD group (34 subjects), which were adjusted for the total score of MMSE. The Student’s t-test, chi-square test, and log-rank test of Kaplan-Meier survival curves were used for statistical analyses. <h3>Results:</h3> A negative correlation between MMSE and age was observed even after the age of 100 years. APOEɛ4, which is highly associated with cognitive dysfunction in general ages, lost effects on the decline in cognitive function after the age of 108. MMSE analysis showed that the scale of the sub-item following 3 step orders was retained in centenarians, while it was reduced in late-phase of AD, being as a specific point of difference. The retention of associative function that transfer spatial cognition to spontaneous actions was a characteristic of centenarians’ cognition. <h3>Conclusions:</h3> Patterns of cognitive impairment in centenarians and Alzheimer9s disease are different. This is one of the most critical points in distinguishing age-related cognitive dysfunction from dementia in clinical practice. <b>Disclosure:</b> Yoshinori Nishimoto has received research support from Japan Society for the Promotion of Science. Dr. Sasaki has nothing to disclose. Miss Abe has nothing to disclose. Ms. Konishi has nothing to disclose. Daisuke Ito has nothing to disclose. Dr. Bun has nothing to disclose. Ms. Otaki has nothing to disclose. Norikazu Hara has nothing to disclose. Dr. Miyashita has nothing to disclose. Dr. Ikeuchi has nothing to disclose. The institution of Prof. Arai has received research support from AMED Cyclic Innovation for Clinical Empowerment (governmental fund)." @default.
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• W4367304849 date "2023-04-25" @default.
• W4367304849 modified "2023-09-26" @default.
• W4367304849 title "Investigation into the Difference of Cognitive Decline between the Centenarians and Alzheimer's Disease (P4-6.004)" @default.
• W4367304849 doi "https://doi.org/10.1212/wnl.0000000000201736" @default.
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