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• W4367304876 abstract "<h3>Objective:</h3> We hypothesize that hypertension goes undiagnosed more frequently in highly deprived neighborhoods and in people from Black race. We also hypothesize that undiagnosed hypertension is associated with a higher risk of incident stroke. <h3>Background:</h3> Neighborhood deprivation is one of the leading social determinants of health and is associated with lower access to clinical care. <h3>Design/Methods:</h3> We conducted a longitudinal study analyzing participants from the All of Us study (AoU). We identified people who met the criteria for hypertension based on blood pressure measurements at the time of enrollment but were not known to have the condition according to EHR or survey data. We evaluated neighborhood deprivation using the Deprivation Index (DI), an aggregate variable derived from six American Community Survey metrics. We used multivariable logistic regression to test for interaction between race and tertiles of DI in a model predicting undiagnosed hypertension adjusting for age, sex, income, and education. <h3>Results:</h3> Of the 372,397 participants enrolled in AoU, 269,063 had data for DI and blood pressure; of these, 6,690(2.5%) sustained a stroke. Compared to low deprivation, intermediate and high deprivation were associated with 3.4%(OR:1.034;95%CI:1.00–1.07) and 17.4% (OR:1.174;95%CI:1.14–1.21) higher risk of undiagnosed hypertension (test-for-trend p<0.0001). Compared to White participants, Black participants had a 67.4%(OR:1.674;95%CI:1.62–1.73;p<0.001) higher risk of undiagnosed hypertension. There was a significant synergy between DI and race (interaction p<0.001): compared to White participants living in areas of low deprivation, Black participants living in highly deprived neighborhoods had 106%(OR:2.06;95%CI:1.96–2.16;p<0.001) higher risk of undiagnosed hypertension. In the whole cohort, undiagnosed hypertension was associated with a 34%(OR:1.34;95%CI:1.12–1.62;p=0.002) higher incident stroke risk when adjusting for prevalent hypertension and the aforementioned socioeconomic factors. <h3>Conclusions:</h3> High neighborhood deprivation and Black race are associated with a higher risk of undiagnosed hypertension, and these effects are synergistic. Undiagnosed hypertension is associated with a higher ischemic stroke risk after accounting for medically diagnosed hypertension. <b>Disclosure:</b> Mr. Torres-Lopez has nothing to disclose. Dr. Renedo has nothing to disclose. Dr. Acosta has nothing to disclose. Thomas Gill has nothing to disclose. Dr. Sheth has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ceribell. Dr. Sheth has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Zoll. Dr. Sheth has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for NControl. Dr. Sheth has received stock or an ownership interest from Astrocyte. Dr. Sheth has received stock or an ownership interest from Alva. The institution of Dr. Sheth has received research support from Biogen. The institution of Dr. Sheth has received research support from Novartis. The institution of Dr. Sheth has received research support from Bard. The institution of Dr. Sheth has received research support from Hyperfine. Dr. Sheth has received intellectual property interests from a discovery or technology relating to health care. The institution of Dr. Falcone has received research support from NIH. The institution of Dr. Falcone has received research support from AHA. Dr. Rivier has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pyxis Partners." @default.
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• W4367304876 date "2023-04-25" @default.
• W4367304876 modified "2023-09-23" @default.
• W4367304876 title "Neighborhood Deprivation and Race Synergistically Contribute to Undiagnosed Hypertension Leading to Acute Ischemic Stroke: Results from the All of Us Research Program (P6-9.001)" @default.
• W4367304876 doi "https://doi.org/10.1212/wnl.0000000000202154" @default.
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