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• W4367304966 abstract "<h3>Objective:</h3> Examine longitudinal changes in cortical gyrification in multiple sclerosis (MS) and the link between cortical reshaping, lesion load, and disability. <h3>Background:</h3> Local gyrification index (LGI) is a measure of the degree and pattern of cortical folding and is associated with worsening disability in neurodegenerative diseases, but is not always correlated with brain or cortical atrophy. In MS, changes in LGI may indicate regions undergoing remodeling. <h3>Design/Methods:</h3> 47 people with MS (29 relapsing-remitting, 15 secondary progressive, 3 primary progressive; age 49±11 years; 65% female; median disease duration 12 years [IQR, 17.5]) underwent longitudinal 3T and 7T brain MRI and disability assessments (median follow-up 2.3 years, range 1.7–4.0). Cortical and white matter lesions were manually segmented on 7T (0.5 mm³ MP2RAGE (median of 4 acquisitions), 0.5 mm³ T2*w GRE) and 3T (FLAIR, MP2RAGE, T2w) images respectively. LGI was measured at each timepoint on 3T MP2RAGE T1w images (Freesurfer 7.1). <h3>Results:</h3> Across the cohort, LGI decreased over time in the cingulate, superior frontal, and medial orbitofrontal gyri (P_FWE<0.05, adjusted for age and sex). Within individual cortical regions, correlation between change in LGI and change in cortical thickness and volume was weak to moderate. The number of cortical areas with ≥5% LGI reduction was associated with worsening timed 25-foot walk (ρ=0.302, <i>P</i>=0.039) and 9-hole peg test (ρ=0.361, <i>P</i>=0.013). Global gyrification decrease was associated with higher cortical (ρ=−0.296, <i>P</i>=0.043) and white matter lesion burden (ρ= −0.303, <i>P</i>=0.039). An age-adjusted backward regression model used to determine the influence of baseline cortical and white matter lesion load on LGI changes predicted 16.2% of LGI variance (<i>P</i>=0.001), and higher cortical lesion burden predicted gyrification loss (β= −0.403, <i>P</i>=0.005). <h3>Conclusions:</h3> Loss of gyrification is associated with worsening disability and lesion burden, especially in the cortex. Further investigation of LGI in MS may elucidate the factors influencing cortical remodeling and how cortical remodeling contributes to disability. <b>Disclosure:</b> Mr. Dos Santos Silva has nothing to disclose. Dr. La Rosa has nothing to disclose. Mr. Mullins has nothing to disclose. Dr. Parvathaneni has nothing to disclose. The institution of Ms. Maranzano has received research support from Natural Sciences and Engineering Research Council of Canada. Dr. Reich has received research support from NIH. The institution of Dr. Reich has received research support from Vertex Pharmaceuticals. The institution of Dr. Reich has received research support from Adelson Medical Research Foundation. The institution of Dr. Reich has received research support from Myelin Repair Foundation. The institution of Dr. Reich has received research support from Sanofi-Genzyme. The institution of Dr. Reich has received research support from Abata Therapeutics. The institution of Dr. Reich has received research support from National Multiple Sclerosis Society. Dr. Reich has received personal compensation in the range of $500-$4,999 for serving as a CME Faculty with PeerView. Dr. Reich has received personal compensation in the range of $500-$4,999 for serving as a CME Faculty with AcademicCME. Dr. Reich has a non-compensated relationship as a Advisor with Sanofi-Genzyme that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Board of Directors with ACTRIMS that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Advisor with Abata Therapeutics that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Advisor with Roche that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Advisor with American Brain Foundation that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Advisor with University of Basel RC2NB that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Advisor with Multiple Sclerosis Society of Canada that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Advisor with Tuscan Doctorate in Neuroscience that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Editorial Board with Multiple Sclerosis Journal that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Advisor with Glaxo-Smith-Kline that is relevant to AAN interests or activities. The institution of Dr. Beck has received research support from National Multiple Sclerosis Society. Dr. Beck has received intellectual property interests from a discovery or technology relating to health care." @default.
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• W4367304966 date "2023-04-25" @default.
• W4367304966 modified "2023-09-26" @default.
• W4367304966 title "Loss of gyrification is associated with disability progression in multiple sclerosis (P10-3.006)" @default.
• W4367304966 doi "https://doi.org/10.1212/wnl.0000000000201750" @default.
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