FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367305213> ?p ?o ?g. }

• W4367305213 abstract "<h3>Objective:</h3> To identify risk factors associated with mortality and poor functional outcomes in patients with central nervous system tuberculosis (CNS TB) cared for in San Francisco, CA. <h3>Background:</h3> CNS TB is one of the most severe forms of TB. Studies evaluating risk factors for mortality and disability due to CNS TB are lacking across low- and high-resource settings. <h3>Design/Methods:</h3> Search terms were used to identify medical records from patients with possible CNS TB at two medical centers in San Francisco, CA between January 1st, 2011, and November 1st, 2021. Data was extracted from a sample (n=75) of cases who met criteria for definite or suspected CNS TB warranting treatment with anti-tuberculous medications. Logistic regression models were performed to identify associations of demographic factors, comorbidities, and clinical signs/symptoms with mortality and functional outcomes. <h3>Results:</h3> Of 75 cases of CNS TB, most were men (60%), 18–64 years of age (67%), foreign-born (75%), and publicly insured (60%). Diabetes (28%) and hypertension (45%) were common comorbidities. The prevalence of HIV (9.8%) was 32 times higher than in the general California population. Many patients experienced long-term moderate to severe impairments in mobility (56%) and cognition (47%) and loss of independent function (50%). Increasing age (OR=1.04 per year, 95%CI:1.00–1.07), hypertension (OR=5.40, 95%CI:1.24–23.10), intubation (OR=9.14, 95%CI: 2.14–39.07), and altered mental status (OR=7.09, 95%CI: 1.61–31.30) were significantly associated with increased odds of mortality. Altered mental status at presentation (p<0.001) and hydrocephalus (p=0.040) were associated with a greater likelihood of long-term cognitive impairment. <h3>Conclusions:</h3> Mortality and functional impairment were common in patients with CNS TB cared for over the past decade in San Francisco. Older patients and those with hypertension had worse outcomes, as did patients presenting with altered mental status and hydrocephalus. Earlier CNS TB diagnosis and more effective treatment, including for patients with select risk factors, are needed to improve outcomes. <b>Disclosure:</b> Mr. HERNANDEZ CASTILLO has nothing to disclose. Dr. Chow has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Medicolegal consulting. The institution of Dr. Chow has received research support from NIH. Dr. Louie has nothing to disclose. Ms. Romo has nothing to disclose." @default.
• W4367305213 created "2023-04-29" @default.
• W4367305213 creator A5035890778 @default.
• W4367305213 creator A5055800721 @default.
• W4367305213 creator A5079093557 @default.
• W4367305213 creator A5089116952 @default.
• W4367305213 date "2023-04-25" @default.
• W4367305213 modified "2023-09-30" @default.
• W4367305213 title "Clinical Factors Associated with Poor Outcomes in Patients with Central Nervous System Tuberculosis Treated in San Francisco, CA from 2011 to 2021 (S25.006)" @default.
• W4367305213 doi "https://doi.org/10.1212/wnl.0000000000203289" @default.
• W4367305213 hasPublicationYear "2023" @default.
• W4367305213 type Work @default.
• W4367305213 citedByCount "0" @default.
• W4367305213 crossrefType "proceedings-article" @default.
• W4367305213 hasAuthorship W4367305213A5035890778 @default.
• W4367305213 hasAuthorship W4367305213A5055800721 @default.
• W4367305213 hasAuthorship W4367305213A5079093557 @default.
• W4367305213 hasAuthorship W4367305213A5089116952 @default.
• W4367305213 hasConcept C126322002 @default.
• W4367305213 hasConcept C134018914 @default.
• W4367305213 hasConcept C142724271 @default.
• W4367305213 hasConcept C151956035 @default.
• W4367305213 hasConcept C167135981 @default.
• W4367305213 hasConcept C187212893 @default.
• W4367305213 hasConcept C195910791 @default.
• W4367305213 hasConcept C2779159551 @default.
• W4367305213 hasConcept C2781069245 @default.
• W4367305213 hasConcept C2908647359 @default.
• W4367305213 hasConcept C555293320 @default.
• W4367305213 hasConcept C71924100 @default.
• W4367305213 hasConcept C99454951 @default.
• W4367305213 hasConceptScore W4367305213C126322002 @default.
• W4367305213 hasConceptScore W4367305213C134018914 @default.
• W4367305213 hasConceptScore W4367305213C142724271 @default.
• W4367305213 hasConceptScore W4367305213C151956035 @default.
• W4367305213 hasConceptScore W4367305213C167135981 @default.
• W4367305213 hasConceptScore W4367305213C187212893 @default.
• W4367305213 hasConceptScore W4367305213C195910791 @default.
• W4367305213 hasConceptScore W4367305213C2779159551 @default.
• W4367305213 hasConceptScore W4367305213C2781069245 @default.
• W4367305213 hasConceptScore W4367305213C2908647359 @default.
• W4367305213 hasConceptScore W4367305213C555293320 @default.
• W4367305213 hasConceptScore W4367305213C71924100 @default.
• W4367305213 hasConceptScore W4367305213C99454951 @default.
• W4367305213 hasLocation W43673052131 @default.
• W4367305213 hasOpenAccess W4367305213 @default.
• W4367305213 hasPrimaryLocation W43673052131 @default.
• W4367305213 hasRelatedWork W11079011 @default.
• W4367305213 hasRelatedWork W2144758187 @default.
• W4367305213 hasRelatedWork W2415759662 @default.
• W4367305213 hasRelatedWork W2776557614 @default.
• W4367305213 hasRelatedWork W2917811744 @default.
• W4367305213 hasRelatedWork W3040890324 @default.
• W4367305213 hasRelatedWork W3188235274 @default.
• W4367305213 hasRelatedWork W4282918061 @default.
• W4367305213 hasRelatedWork W4322711975 @default.
• W4367305213 hasRelatedWork W2571824586 @default.
• W4367305213 isParatext "false" @default.
• W4367305213 isRetracted "false" @default.
• W4367305213 workType "article" @default.