Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367307842> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4367307842 abstract "Antibiotics are drugs that have revolutionized the world scenario for the treatment of infectious diseases caused by bacteria and have reduced morbidity and mortality rates worldwide. Due to the increase in population and veterinary treatment, the use of medicines for health and treatment in animals has increased considerably. In this context, the present study aimed to evaluate the potential pharmacokinetic and toxicological impacts of the veterinary antibiotic Cephalonium on human and environmental health. In this work, predictions of molecular properties for the antibiotic were performed with the aid of in silico methodologies. In silico pharmacokinetic studies have shown promising results, as the antibiotic has a low rate of human intestinal absorption, is not permeable by the blood-brain barrier, and does not inhibit hepatic isoenzymes. The antibiotic showed promising data about the Ames test, showing itself to be non-toxic (non-mutagenic), not carcinogenic, with acute oral toxicity classified as category III (low human toxicity). In the in silico evaluations of environmental toxicity, Cephalonium was not toxic for bees and crustaceans, however, it showed a toxicity for fish. Therefore, it is noteworthy that Cephalonium promotes environmental and consequently human contamination by the presence of antibiotic residues present in food." @default.
- W4367307842 created "2023-04-29" @default.
- W4367307842 creator A5018381487 @default.
- W4367307842 creator A5030492567 @default.
- W4367307842 date "2023-04-28" @default.
- W4367307842 modified "2023-10-01" @default.
- W4367307842 title "In silico pharmacokinetic and toxicological evaluation of Cephalonium antibiotic in human and environmental health" @default.
- W4367307842 doi "https://doi.org/10.56238/alookdevelopv1-001" @default.
- W4367307842 hasPublicationYear "2023" @default.
- W4367307842 type Work @default.
- W4367307842 citedByCount "0" @default.
- W4367307842 crossrefType "book-chapter" @default.
- W4367307842 hasAuthorship W4367307842A5018381487 @default.
- W4367307842 hasAuthorship W4367307842A5030492567 @default.
- W4367307842 hasBestOaLocation W43673078421 @default.
- W4367307842 hasConcept C104317684 @default.
- W4367307842 hasConcept C112705442 @default.
- W4367307842 hasConcept C116263406 @default.
- W4367307842 hasConcept C126322002 @default.
- W4367307842 hasConcept C151730666 @default.
- W4367307842 hasConcept C185867374 @default.
- W4367307842 hasConcept C2775905019 @default.
- W4367307842 hasConcept C2779343474 @default.
- W4367307842 hasConcept C29730261 @default.
- W4367307842 hasConcept C2987857752 @default.
- W4367307842 hasConcept C33070731 @default.
- W4367307842 hasConcept C501593827 @default.
- W4367307842 hasConcept C55493867 @default.
- W4367307842 hasConcept C71924100 @default.
- W4367307842 hasConcept C86803240 @default.
- W4367307842 hasConcept C89423630 @default.
- W4367307842 hasConcept C98274493 @default.
- W4367307842 hasConcept C99454951 @default.
- W4367307842 hasConceptScore W4367307842C104317684 @default.
- W4367307842 hasConceptScore W4367307842C112705442 @default.
- W4367307842 hasConceptScore W4367307842C116263406 @default.
- W4367307842 hasConceptScore W4367307842C126322002 @default.
- W4367307842 hasConceptScore W4367307842C151730666 @default.
- W4367307842 hasConceptScore W4367307842C185867374 @default.
- W4367307842 hasConceptScore W4367307842C2775905019 @default.
- W4367307842 hasConceptScore W4367307842C2779343474 @default.
- W4367307842 hasConceptScore W4367307842C29730261 @default.
- W4367307842 hasConceptScore W4367307842C2987857752 @default.
- W4367307842 hasConceptScore W4367307842C33070731 @default.
- W4367307842 hasConceptScore W4367307842C501593827 @default.
- W4367307842 hasConceptScore W4367307842C55493867 @default.
- W4367307842 hasConceptScore W4367307842C71924100 @default.
- W4367307842 hasConceptScore W4367307842C86803240 @default.
- W4367307842 hasConceptScore W4367307842C89423630 @default.
- W4367307842 hasConceptScore W4367307842C98274493 @default.
- W4367307842 hasConceptScore W4367307842C99454951 @default.
- W4367307842 hasLocation W43673078421 @default.
- W4367307842 hasOpenAccess W4367307842 @default.
- W4367307842 hasPrimaryLocation W43673078421 @default.
- W4367307842 hasRelatedWork W2000200648 @default.
- W4367307842 hasRelatedWork W2068005011 @default.
- W4367307842 hasRelatedWork W2293351877 @default.
- W4367307842 hasRelatedWork W2956596586 @default.
- W4367307842 hasRelatedWork W3212117736 @default.
- W4367307842 hasRelatedWork W4206966109 @default.
- W4367307842 hasRelatedWork W4307092588 @default.
- W4367307842 hasRelatedWork W4308352595 @default.
- W4367307842 hasRelatedWork W4309723377 @default.
- W4367307842 hasRelatedWork W4377967821 @default.
- W4367307842 isParatext "false" @default.
- W4367307842 isRetracted "false" @default.
- W4367307842 workType "book-chapter" @default.