Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367310410> ?p ?o ?g. }
- W4367310410 endingPage "1188" @default.
- W4367310410 startingPage "1179" @default.
- W4367310410 abstract "Apigenin (APG) is a well-known dietary flavonoid with multiple bioactivities, but its poor aqueous solubility may result in low oral bioavailability and thus compromised therapeutic effects. In the present study, APG was complexed with oxymatrine (OMT), a natural quinolizidine alkaloid, for enhanced anti-inflammatory activity, and the related mechanisms in the interaction of APG with OMT were investigated. Fourier transform-infrared spectroscopy, fluorescence spectroscopy, Raman spectroscopy, and proton nuclear magnetic resonance spectroscopy characterizations demonstrated the occurrence of an APG–OMT complex formed at a molar ratio of 1:2. Then, molecular dynamics simulations and quantum chemical calculations were utilized to elucidate that hydrogen bonding, van der Waals forces, and hydrophobic effects were the main forces acting in the formation of the APG–OMT complex. Pharmacokinetic studies in rats demonstrated that the oral bioavailability of APG in the APG–OMT complex was significantly higher than that of APG alone. Finally, bioactivity evaluation in the lipopolysaccharide-induced acute inflammatory injury mouse models showed that the APG–OMT complex exhibited more potent anti-inflammatory effects than APG alone. This study confirmed that APG and OMT exerted enhanced anti-inflammatory effects through self-complexation, which may provide a novel strategy for improving the bioavailability and bioactivity of natural product mixtures." @default.
- W4367310410 created "2023-04-29" @default.
- W4367310410 creator A5008398353 @default.
- W4367310410 creator A5019281354 @default.
- W4367310410 creator A5021984184 @default.
- W4367310410 creator A5029695887 @default.
- W4367310410 creator A5050038192 @default.
- W4367310410 creator A5056360877 @default.
- W4367310410 creator A5058551020 @default.
- W4367310410 creator A5059006331 @default.
- W4367310410 creator A5081057106 @default.
- W4367310410 creator A5087382922 @default.
- W4367310410 date "2023-04-28" @default.
- W4367310410 modified "2023-10-01" @default.
- W4367310410 title "Complexation of Apigenin and Oxymatrine Leading to Enhanced Anti-inflammatory Activity" @default.
- W4367310410 cites W1965196524 @default.
- W4367310410 cites W2012268849 @default.
- W4367310410 cites W2036260922 @default.
- W4367310410 cites W2038433879 @default.
- W4367310410 cites W2045979060 @default.
- W4367310410 cites W2083072576 @default.
- W4367310410 cites W2085441718 @default.
- W4367310410 cites W2131868229 @default.
- W4367310410 cites W2147304506 @default.
- W4367310410 cites W2148126686 @default.
- W4367310410 cites W2149591934 @default.
- W4367310410 cites W2237260456 @default.
- W4367310410 cites W2321933333 @default.
- W4367310410 cites W2332079989 @default.
- W4367310410 cites W2526141956 @default.
- W4367310410 cites W2560550958 @default.
- W4367310410 cites W2560925171 @default.
- W4367310410 cites W2604288951 @default.
- W4367310410 cites W2606399170 @default.
- W4367310410 cites W2748218427 @default.
- W4367310410 cites W2765596630 @default.
- W4367310410 cites W2767531132 @default.
- W4367310410 cites W2886056161 @default.
- W4367310410 cites W2895019300 @default.
- W4367310410 cites W2898873799 @default.
- W4367310410 cites W2909586457 @default.
- W4367310410 cites W2911759928 @default.
- W4367310410 cites W2921026906 @default.
- W4367310410 cites W2921088573 @default.
- W4367310410 cites W2935867226 @default.
- W4367310410 cites W2945989190 @default.
- W4367310410 cites W2969736881 @default.
- W4367310410 cites W2987953740 @default.
- W4367310410 cites W2994540222 @default.
- W4367310410 cites W2995322103 @default.
- W4367310410 cites W3003182094 @default.
- W4367310410 cites W3008428389 @default.
- W4367310410 cites W3010935319 @default.
- W4367310410 cites W3013100798 @default.
- W4367310410 cites W3082240054 @default.
- W4367310410 cites W3089239867 @default.
- W4367310410 cites W3128786306 @default.
- W4367310410 cites W3145419629 @default.
- W4367310410 cites W3152049133 @default.
- W4367310410 cites W3179055083 @default.
- W4367310410 cites W3210009031 @default.
- W4367310410 cites W4206945946 @default.
- W4367310410 doi "https://doi.org/10.1021/acs.jnatprod.2c00947" @default.
- W4367310410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37115657" @default.
- W4367310410 hasPublicationYear "2023" @default.
- W4367310410 type Work @default.
- W4367310410 citedByCount "1" @default.
- W4367310410 crossrefType "journal-article" @default.
- W4367310410 hasAuthorship W4367310410A5008398353 @default.
- W4367310410 hasAuthorship W4367310410A5019281354 @default.
- W4367310410 hasAuthorship W4367310410A5021984184 @default.
- W4367310410 hasAuthorship W4367310410A5029695887 @default.
- W4367310410 hasAuthorship W4367310410A5050038192 @default.
- W4367310410 hasAuthorship W4367310410A5056360877 @default.
- W4367310410 hasAuthorship W4367310410A5058551020 @default.
- W4367310410 hasAuthorship W4367310410A5059006331 @default.
- W4367310410 hasAuthorship W4367310410A5081057106 @default.
- W4367310410 hasAuthorship W4367310410A5087382922 @default.
- W4367310410 hasConcept C150903083 @default.
- W4367310410 hasConcept C178790620 @default.
- W4367310410 hasConcept C181389837 @default.
- W4367310410 hasConcept C185592680 @default.
- W4367310410 hasConcept C207001950 @default.
- W4367310410 hasConcept C2776245682 @default.
- W4367310410 hasConcept C2778004101 @default.
- W4367310410 hasConcept C2778609962 @default.
- W4367310410 hasConcept C2779054382 @default.
- W4367310410 hasConcept C2779703632 @default.
- W4367310410 hasConcept C2781263971 @default.
- W4367310410 hasConcept C43617362 @default.
- W4367310410 hasConcept C66974803 @default.
- W4367310410 hasConcept C71240020 @default.
- W4367310410 hasConcept C86803240 @default.
- W4367310410 hasConcept C98274493 @default.
- W4367310410 hasConceptScore W4367310410C150903083 @default.
- W4367310410 hasConceptScore W4367310410C178790620 @default.
- W4367310410 hasConceptScore W4367310410C181389837 @default.
- W4367310410 hasConceptScore W4367310410C185592680 @default.