FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367310478> ?p ?o ?g. }

• W4367310478 abstract "Several types of benign and malignant uveal melanocytes have been described based on their histological appearance. However, their characteristics have not been quantified, and their distribution during progression from normal choroidal melanocytes to primary tumors and metastases has not been reported.A total of 1,245,411 digitally scanned melanocytes from normal choroid, choroidal nevi, primary uveal melanomas, and liver metastases were entered into two-step cluster analyses to delineate cell types based on measured morphometric characteristics and expression of protein markers.Here we show that a combination of the area and circularity of cell nuclei, and BAP-1 expression in nuclei and cytoplasms yields the highest silhouette of cohesion and separation. Normal choroidal melanocytes and three types of uveal melanoma cells are outlined: Epithelioid (large, rounded nuclei; BAP-1 low; IGF-1R, IDO, and TIGIT high), spindle A (small, elongated nuclei; BAP-1 high; IGF-1R low; IDO, and TIGIT intermediate), and spindle B (large, elongated nuclei; BAP-1, IGF-1R, IDO, and TIGIT low). In normal choroidal tissue and nevi, only normal melanocytes and spindle A cells are represented. Epithelioid and spindle B cells are overrepresented in the base and apex, and spindle A cells in the center of primary tumors. Liver metastases contain no normal melanocytes or spindle A cells.Four basic cell types can be outlined in uveal melanoma progression: normal, spindle A and B, and epithelioid. Differential expression of tumor suppressors, growth factors, and immune checkpoints could contribute to their relative over- and underrepresentation in benign, primary tumor, and metastatic samples.In this study, we take a close look on more than a million cells of the type that makes pigment inside the eye. Sometimes these cells become cancers called uveal melanomas, that have a high risk of killing the patient. The cells were digitally scanned and we measured their size, shape, and content of different proteins that are important for how they behave. We find that four types of cells are present in different proportions in normal tissue, moles, eye tumors, and tumor tissue that has spread to other parts of the body. This knowledge is important as it improves our understanding of what cells form uveal melanomas, and of how they are distributed over different stages of the disease. In turn, this could help researchers focus on the right type of cells in our pursuit of effective treatments." @default.
• W4367310478 created "2023-04-29" @default.
• W4367310478 creator A5026675262 @default.
• W4367310478 creator A5056669160 @default.
• W4367310478 date "2023-04-28" @default.
• W4367310478 modified "2023-10-08" @default.
• W4367310478 title "Digital morphometry and cluster analysis identifies four types of melanocyte during uveal melanoma progression" @default.
• W4367310478 cites W1502106409 @default.
• W4367310478 cites W1552595466 @default.
• W4367310478 cites W1967790688 @default.
• W4367310478 cites W1969879451 @default.
• W4367310478 cites W1970068068 @default.
• W4367310478 cites W1990403579 @default.
• W4367310478 cites W2012836981 @default.
• W4367310478 cites W2027998941 @default.
• W4367310478 cites W2037130387 @default.
• W4367310478 cites W2041937596 @default.
• W4367310478 cites W2057802075 @default.
• W4367310478 cites W2067354849 @default.
• W4367310478 cites W2073433320 @default.
• W4367310478 cites W2077539565 @default.
• W4367310478 cites W2097766776 @default.
• W4367310478 cites W2098835477 @default.
• W4367310478 cites W2115246864 @default.
• W4367310478 cites W2117255875 @default.
• W4367310478 cites W2281707699 @default.
• W4367310478 cites W2287628440 @default.
• W4367310478 cites W2326993272 @default.
• W4367310478 cites W2506618086 @default.
• W4367310478 cites W2746164323 @default.
• W4367310478 cites W2771177310 @default.
• W4367310478 cites W2779273646 @default.
• W4367310478 cites W2789955711 @default.
• W4367310478 cites W2939988911 @default.
• W4367310478 cites W2952481429 @default.
• W4367310478 cites W2974328106 @default.
• W4367310478 cites W2980804896 @default.
• W4367310478 cites W3002671583 @default.
• W4367310478 cites W3007815704 @default.
• W4367310478 cites W3134810113 @default.
• W4367310478 cites W3159433497 @default.
• W4367310478 cites W4214643770 @default.
• W4367310478 cites W4220838866 @default.
• W4367310478 doi "https://doi.org/10.1038/s43856-023-00291-z" @default.
• W4367310478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37117276" @default.
• W4367310478 hasPublicationYear "2023" @default.
• W4367310478 type Work @default.
• W4367310478 citedByCount "0" @default.
• W4367310478 crossrefType "journal-article" @default.
• W4367310478 hasAuthorship W4367310478A5026675262 @default.
• W4367310478 hasAuthorship W4367310478A5056669160 @default.
• W4367310478 hasBestOaLocation W43673104781 @default.
• W4367310478 hasConcept C118441373 @default.
• W4367310478 hasConcept C142724271 @default.
• W4367310478 hasConcept C169760540 @default.
• W4367310478 hasConcept C203014093 @default.
• W4367310478 hasConcept C204232928 @default.
• W4367310478 hasConcept C2776090121 @default.
• W4367310478 hasConcept C2776694393 @default.
• W4367310478 hasConcept C2776713392 @default.
• W4367310478 hasConcept C2777093970 @default.
• W4367310478 hasConcept C2777658100 @default.
• W4367310478 hasConcept C2779118045 @default.
• W4367310478 hasConcept C2779769559 @default.
• W4367310478 hasConcept C502942594 @default.
• W4367310478 hasConcept C71924100 @default.
• W4367310478 hasConcept C86803240 @default.
• W4367310478 hasConcept C8891405 @default.
• W4367310478 hasConceptScore W4367310478C118441373 @default.
• W4367310478 hasConceptScore W4367310478C142724271 @default.
• W4367310478 hasConceptScore W4367310478C169760540 @default.
• W4367310478 hasConceptScore W4367310478C203014093 @default.
• W4367310478 hasConceptScore W4367310478C204232928 @default.
• W4367310478 hasConceptScore W4367310478C2776090121 @default.
• W4367310478 hasConceptScore W4367310478C2776694393 @default.
• W4367310478 hasConceptScore W4367310478C2776713392 @default.
• W4367310478 hasConceptScore W4367310478C2777093970 @default.
• W4367310478 hasConceptScore W4367310478C2777658100 @default.
• W4367310478 hasConceptScore W4367310478C2779118045 @default.
• W4367310478 hasConceptScore W4367310478C2779769559 @default.
• W4367310478 hasConceptScore W4367310478C502942594 @default.
• W4367310478 hasConceptScore W4367310478C71924100 @default.
• W4367310478 hasConceptScore W4367310478C86803240 @default.
• W4367310478 hasConceptScore W4367310478C8891405 @default.
• W4367310478 hasIssue "1" @default.
• W4367310478 hasLocation W43673104781 @default.
• W4367310478 hasLocation W43673104782 @default.
• W4367310478 hasLocation W43673104783 @default.
• W4367310478 hasOpenAccess W4367310478 @default.
• W4367310478 hasPrimaryLocation W43673104781 @default.
• W4367310478 hasRelatedWork W1967793798 @default.
• W4367310478 hasRelatedWork W1984288111 @default.
• W4367310478 hasRelatedWork W2008481914 @default.
• W4367310478 hasRelatedWork W2018618955 @default.
• W4367310478 hasRelatedWork W2024283519 @default.
• W4367310478 hasRelatedWork W2055427506 @default.
• W4367310478 hasRelatedWork W2411606632 @default.
• W4367310478 hasRelatedWork W2412430727 @default.
• W4367310478 hasRelatedWork W4236219224 @default.
• W4367310478 hasRelatedWork W4367310478 @default.

• next