Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367310583> ?p ?o ?g. }
- W4367310583 abstract "As the autophagosome forms, its membrane surface area expands rapidly, while its volume is kept low. Protein-mediated transfer of lipids from another organelle to the autophagosome likely drives this expansion, but as these lipids are only introduced into the cytoplasmic-facing leaflet of the organelle, full membrane growth also requires lipid scramblase activity. ATG9 harbors scramblase activity and is essential to autophagosome formation; however, whether ATG9 is integrated into mammalian autophagosomes remains unclear. Here we show that in the absence of lipid transport, ATG9 vesicles are already competent to collect proteins found on mature autophagosomes, including LC3-II. Further, we use styrene–maleic acid lipid particles to reveal the nanoscale organization of protein on LC3-II membranes; ATG9 and LC3-II are each fully integrated into expanding autophagosomes. The ratios of these two proteins at different stages of maturation demonstrate that ATG9 proteins are not continuously integrated, but rather are present on the seed vesicles only and become diluted in the expanding autophagosome membrane." @default.
- W4367310583 created "2023-04-29" @default.
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- W4367310583 date "2023-04-28" @default.
- W4367310583 modified "2023-10-16" @default.
- W4367310583 title "ATG9 vesicles comprise the seed membrane of mammalian autophagosomes" @default.
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- W4367310583 cites W1970254771 @default.
- W4367310583 cites W1977709885 @default.
- W4367310583 cites W1993902882 @default.
- W4367310583 cites W1994423882 @default.
- W4367310583 cites W2002174599 @default.
- W4367310583 cites W2017828774 @default.
- W4367310583 cites W2018302034 @default.
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- W4367310583 cites W2045373134 @default.
- W4367310583 cites W2065031087 @default.
- W4367310583 cites W2073672620 @default.
- W4367310583 cites W2089587226 @default.
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- W4367310583 cites W2094241924 @default.
- W4367310583 cites W2109167860 @default.
- W4367310583 cites W2114847797 @default.
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- W4367310583 cites W2768173030 @default.
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- W4367310583 doi "https://doi.org/10.1083/jcb.202208088" @default.
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- W4367310583 hasPublicationYear "2023" @default.
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