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- W4367310691 abstract "Purpose: Adult mammals are incapable of multi-tissue regeneration and augmentation of this potential may drastically shift current therapeutic paradigms. The loss of regenerative capacity in the adult may be due to the inability to activate a pro-regenerative process, which may be in turn suppressed by the dysregulated levels of inflammatory response. IL-6 family of cytokines, which signal through glycoprotein 130 (gp130) receptor, are pleiotropic key players in inflammatory responses following injury that can promote both, regeneration and pathogenesis, depending on the perseverance of inflammatory signal. The bimodal ability of IL-6/g130 signaling mechanism to simultaneously enhance regeneration and promote inflammation and fibrosis is still unclear and this gap in knowledge persists. This suggests that the divergence in outcomes downstream of gp130 are differentially regulated, which imparts the need for identification of a novel specific modality within this network that can be manipulated to initiate beneficial outcomes." @default.
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- W4367310691 date "2023-05-01" @default.
- W4367310691 modified "2023-10-14" @default.
- W4367310691 title "Inhibition of a signaling modality within gp130 receptor enhances tissue regeneration and mitigates osteoarthritis" @default.
- W4367310691 doi "https://doi.org/10.1016/j.joca.2023.02.037" @default.
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