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• W4367310859 startingPage "472" @default.
• W4367310859 abstract "It is now generally accepted that the role of bile acids in the organism is not limited to their participation in the process of food digestion. Indeed, bile acids are signaling molecules and being amphiphilic compounds, are also capable of modifying the properties of cell membranes and their organelles. This review is devoted to the analysis of data on the interaction of bile acids with biological and artificial membranes, in particular, their protonophore and ionophore effects. The effects of bile acids were analyzed depending on their physicochemical properties: namely the structure of their molecules, indicators of the hydrophobic-hydrophilic balance, and the critical micelle concentration. Particular attention is paid to the interaction of bile acids with the powerhouse of cells, the mitochondria. It is of note that bile acids, in addition to their protonophore and ionophore actions, can also induce Ca2+-dependent nonspecific permeability of the inner mitochondrial membrane. We consider the unique action of ursodeoxycholic acid as an inducer of potassium conductivity of the inner mitochondrial membrane. We also discuss a possible relationship between this K+ ionophore action of ursodeoxycholic acid and its therapeutic effects." @default.
• W4367310859 created "2023-04-29" @default.
• W4367310859 creator A5033616879 @default.
• W4367310859 creator A5037236045 @default.
• W4367310859 creator A5037465425 @default.
• W4367310859 creator A5087301244 @default.
• W4367310859 creator A5089252258 @default.
• W4367310859 date "2023-04-28" @default.
• W4367310859 modified "2023-10-01" @default.
• W4367310859 title "Bile Acids as Inducers of Protonophore and Ionophore Permeability of Biological and Artificial Membranes" @default.
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