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• W4367312060 endingPage "698.e3" @default.
• W4367312060 startingPage "683" @default.
• W4367312060 abstract "•Comprehensive repository for human cysteine chemoproteomics data •Enrichment of ligandable cysteines in undruggable classes of proteins •Visualization of lead compounds for 9,246 cysteines •Web app includes annotations of functionality, druggability, and structural motifs Cysteine chemoproteomics provides proteome-wide portraits of the ligandability or potential “druggability” for thousands of cysteine residues. Consequently, these studies are facilitating resources for closing the druggability gap, namely, achieving pharmacological manipulation of ∼96% of the human proteome that remains untargeted by U.S. Food and Drug Administration (FDA) approved small molecules. Recent interactive datasets have enabled users to interface more readily with cysteine chemoproteomics datasets. However, these resources remain limited to single studies and therefore do not provide a mechanism to perform cross-study analyses. Here we report CysDB as a curated community-wide repository of human cysteine chemoproteomics data derived from nine high-coverage studies. CysDB is publicly available at https://backuslab.shinyapps.io/cysdb/ and features measures of identification for 62,888 cysteines (24% of the cysteinome), as well as annotations of functionality, druggability, disease relevance, genetic variation, and structural features. Most importantly, we have designed CysDB to incorporate new datasets to further support the continued growth of the druggable cysteinome. Cysteine chemoproteomics provides proteome-wide portraits of the ligandability or potential “druggability” for thousands of cysteine residues. Consequently, these studies are facilitating resources for closing the druggability gap, namely, achieving pharmacological manipulation of ∼96% of the human proteome that remains untargeted by U.S. Food and Drug Administration (FDA) approved small molecules. Recent interactive datasets have enabled users to interface more readily with cysteine chemoproteomics datasets. However, these resources remain limited to single studies and therefore do not provide a mechanism to perform cross-study analyses. Here we report CysDB as a curated community-wide repository of human cysteine chemoproteomics data derived from nine high-coverage studies. CysDB is publicly available at https://backuslab.shinyapps.io/cysdb/ and features measures of identification for 62,888 cysteines (24% of the cysteinome), as well as annotations of functionality, druggability, disease relevance, genetic variation, and structural features. Most importantly, we have designed CysDB to incorporate new datasets to further support the continued growth of the druggable cysteinome." @default.
• W4367312060 created "2023-04-29" @default.
• W4367312060 creator A5032077859 @default.
• W4367312060 creator A5065677258 @default.
• W4367312060 creator A5069923863 @default.
• W4367312060 creator A5081018257 @default.
• W4367312060 date "2023-06-01" @default.
• W4367312060 modified "2023-10-11" @default.
• W4367312060 title "CysDB: a human cysteine database based on experimental quantitative chemoproteomics" @default.
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• W4367312060 doi "https://doi.org/10.1016/j.chembiol.2023.04.004" @default.
• W4367312060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37119813" @default.
• W4367312060 hasPublicationYear "2023" @default.
• W4367312060 type Work @default.

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