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- W4367312533 abstract "Abstract OBJECTIVE Sporadic bacterial cystitis in both dogs and humans is often caused by Escherichia coli. In humans, nitrofurantoin is a first-line antimicrobial for the treatment of bacterial cystitis but in dogs a lack of available data may be part of the reason it is only recommended as a second-line treatment. The objective of this preliminary study was to determine the plasma pharmacokinetics and urine concentrations of nitrofurantoin monohydrate-macrocrystalline in dogs. ANIMALS 8 healthy female hound dogs. PROCEDURES From July 26 to July 28, 2021, dogs received a single oral dose of nitrofurantoin monohydrate-macrocrystalline 100 mg with food. Blood and urine were collected at predetermined times. Nitrofurantoin concentrations were assayed by UPLC-MS/MS and plasma data were analyzed using noncompartmental methods. RESULTS Plasma concentrations were low for all dogs with a mean ± SD maximum concentration (C max ) of 0.242 ± 0.098 μg/mL (range, 0.14 to 0.42 µg/mL) occurring between 2 and 24 hours. Urine concentrations were manyfold higher than for plasma. C max in urine was 134 ± 54 µg/mL (range, 49.1 to 218 µg/mL) occurring between 6 and 36 hours. As seen in other species, nitrofurantoin concentrated in urine with concentrations being 500 times higher than the concentration in plasma. CLINICAL RELEVANCE Results suggested that nitrofurantoin monohydrate-macrocrystalline formulation of nitrofurantoin should be effective in treating bacterial cystitis caused by susceptible uropathogens." @default.
- W4367312533 created "2023-04-29" @default.
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- W4367312533 date "2023-04-28" @default.
- W4367312533 modified "2023-10-16" @default.
- W4367312533 title "Oral administration of an extended-release formulation of nitrofurantoin results in high concentrations in the urine of dogs" @default.
- W4367312533 doi "https://doi.org/10.2460/javma.22.12.0549" @default.
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- W4367312533 hasPublicationYear "2023" @default.
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