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- W4367315020 abstract "Brain white matter (WM) networks have been widely studied in neuropsychiatric disorders. However, few studies have evaluated alterations in WM network topological organization in patients with methamphetamine (MA) dependence. Therefore, using machine learning classification methods to analyze WM network topological attributes may give new insights into patients with MA dependence. In the study, diffusion tensor imaging-based probabilistic tractography was used to map the weighted WM networks in 46 MA-dependent patients and 46 control subjects. Using graph-theoretical analyses, the global and regional topological attributes of WM networks for both groups were calculated and compared to determine inter-group differences using a permutation-based general linear model. In addition, the study used a support vector machine (SVM) learning approach to construct a classifier for discriminating subjects with MA dependence from control subjects. Relative to the control group, the MA-dependent group exhibited abnormal topological organization, as evidenced by decreased small-worldness and modularity, and increased nodal efficiency in the right medial superior temporal gyrus, right pallidum, and right ventromedial putamen; the MA-dependent group had the higher hubness scores in 25 regions, which were mainly located in the default mode network. An SVM trained with topological attributes achieved classification accuracy, sensitivity, specificity, and kappa values of 98.09% ± 2.59%, 98.24% ± 4.00%, 97.94% ± 4.26%, and 96.18% ± 5.19% for patients with MA dependence. Our results may suggest altered global WM structural networks in MA-dependent patients. Furthermore, the abnormal WM network topological attributes may provide promising features for the construction of high-efficacy classification models." @default.
- W4367315020 created "2023-04-29" @default.
- W4367315020 creator A5007554229 @default.
- W4367315020 creator A5013194203 @default.
- W4367315020 creator A5050047389 @default.
- W4367315020 creator A5060680516 @default.
- W4367315020 creator A5068379269 @default.
- W4367315020 creator A5087279766 @default.
- W4367315020 creator A5091394665 @default.
- W4367315020 date "2023-04-28" @default.
- W4367315020 modified "2023-09-26" @default.
- W4367315020 title "Aberrant topology of white matter networks in patients with methamphetamine dependence and its application in support vector machine-based classification" @default.
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