FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367316074> ?p ?o ?g. }

• W4367316074 endingPage "1814" @default.
• W4367316074 startingPage "1814" @default.
• W4367316074 abstract "Probiotic supplementation is a key therapeutic strategy for promoting gut health and maintaining gut homeostasis by modulating functional microbiota. In this study, we isolated two lactic acid bacteria (LAB) strains, Pediococcus pentosaceus TCM-3 and Lacticaseibacillus paracasei TDM-2, from Qinghai-Tibetan plateau, and evaluated their probiotic properties and antioxidant bioactivity. In which, TDM-2 had higher T-AOC activity than either TCM-3 or LGG (4.10 μmol/mL vs. 3.68 and 3.53 μmol/mL, respectively, p < 0.05). These strains have shown high antioxidant activity compared to the LAB strains and were found to be acid and bile salt tolerant, confronting the safety issues of antibiotic resistance and the capability of surviving in simulated gastric and intestinal juices. In vitro fermentation experiments with human gut microbiota revealed significant differences in microbial community composition between samples supplemented with TCM-3 and TDM-2 and those without. The addition of these two strains resulted in an enrichment of beneficial taxa, such as the Pediococcus, Lactobacillus, and Clostridium_sensu_strictos at the genus level, and Firmicutes and Proteobacteria at the phylum level. Notably, the TCM-3 group exhibited higher short-chain fatty acid production than the TDM-2 group and untreated controls (acetic acid at 12 h: 4.54 mmol L-1 vs. 4.06 mmol L-1 and 4.00 mmol L-1; acetic acid at 24 h: 4.99 mmol L-1 vs. 4.90 mmol L-1 and 4.82 mmol L-1, p < 0.05). These findings demonstrate that LAB supplementation with high antioxidant capacity and probiotic properties can promote gut health by modulating functional microbiota and is enriching for beneficial taxa. Our study provides guidance for therapeutic strategies that use novel LAB strains to maintain gut homeostasis and functional microbiota modulation." @default.
• W4367316074 created "2023-04-29" @default.
• W4367316074 creator A5010760733 @default.
• W4367316074 creator A5012152145 @default.
• W4367316074 creator A5029439092 @default.
• W4367316074 creator A5047659429 @default.
• W4367316074 creator A5059985910 @default.
• W4367316074 creator A5061702055 @default.
• W4367316074 creator A5063414683 @default.
• W4367316074 creator A5080568491 @default.
• W4367316074 creator A5088222762 @default.
• W4367316074 date "2023-04-27" @default.
• W4367316074 modified "2023-10-14" @default.
• W4367316074 title "High Antioxidant Capacity of Lacticaseibacillus paracasei TDM-2 and Pediococcus pentosaceus TCM-3 from Qinghai Tibetan Plateau and Their Function towards Gut Modulation" @default.
• W4367316074 cites W1529102077 @default.
• W4367316074 cites W1647551795 @default.
• W4367316074 cites W1775367418 @default.
• W4367316074 cites W1805886987 @default.
• W4367316074 cites W188910559 @default.
• W4367316074 cites W1964717752 @default.
• W4367316074 cites W1969064923 @default.
• W4367316074 cites W1974707233 @default.
• W4367316074 cites W1978095252 @default.
• W4367316074 cites W1982189992 @default.
• W4367316074 cites W1990590570 @default.
• W4367316074 cites W1993385887 @default.
• W4367316074 cites W1993952575 @default.
• W4367316074 cites W2001210103 @default.
• W4367316074 cites W2002118134 @default.
• W4367316074 cites W2007187838 @default.
• W4367316074 cites W2018763962 @default.
• W4367316074 cites W2020373649 @default.
• W4367316074 cites W2023677185 @default.
• W4367316074 cites W2024000103 @default.
• W4367316074 cites W2035097873 @default.
• W4367316074 cites W2037433601 @default.
• W4367316074 cites W2040335930 @default.
• W4367316074 cites W2041633812 @default.
• W4367316074 cites W2058200139 @default.
• W4367316074 cites W2068145027 @default.
• W4367316074 cites W2068484477 @default.
• W4367316074 cites W2073139566 @default.
• W4367316074 cites W2075968873 @default.
• W4367316074 cites W2077970652 @default.
• W4367316074 cites W2079252712 @default.
• W4367316074 cites W2086758072 @default.
• W4367316074 cites W2090393270 @default.
• W4367316074 cites W2092927777 @default.
• W4367316074 cites W2103337472 @default.
• W4367316074 cites W2149716668 @default.
• W4367316074 cites W2150356537 @default.
• W4367316074 cites W2166134706 @default.
• W4367316074 cites W2228571342 @default.
• W4367316074 cites W2409656339 @default.
• W4367316074 cites W2539598072 @default.
• W4367316074 cites W2543259773 @default.
• W4367316074 cites W2555804104 @default.
• W4367316074 cites W2557877215 @default.
• W4367316074 cites W2565510401 @default.
• W4367316074 cites W2594607931 @default.
• W4367316074 cites W2617716806 @default.
• W4367316074 cites W2754890845 @default.
• W4367316074 cites W2790370685 @default.
• W4367316074 cites W2946372752 @default.
• W4367316074 cites W2955824445 @default.
• W4367316074 cites W2983030228 @default.
• W4367316074 cites W2994793588 @default.
• W4367316074 cites W3014868659 @default.
• W4367316074 cites W3033931596 @default.
• W4367316074 cites W3044003116 @default.
• W4367316074 cites W3049198931 @default.
• W4367316074 cites W3096586635 @default.
• W4367316074 cites W3118480240 @default.
• W4367316074 cites W3140225247 @default.
• W4367316074 cites W3159519727 @default.
• W4367316074 cites W3162076795 @default.
• W4367316074 cites W3166500277 @default.
• W4367316074 cites W3184146378 @default.
• W4367316074 cites W3184382693 @default.
• W4367316074 cites W3207882493 @default.
• W4367316074 cites W3208655526 @default.
• W4367316074 cites W3211533091 @default.
• W4367316074 cites W3211724141 @default.
• W4367316074 cites W4206681139 @default.
• W4367316074 cites W4220791047 @default.
• W4367316074 cites W4253897310 @default.
• W4367316074 cites W4283646889 @default.
• W4367316074 cites W4284994451 @default.
• W4367316074 cites W4285091711 @default.
• W4367316074 cites W4291173113 @default.
• W4367316074 cites W4315928203 @default.
• W4367316074 cites W4328128694 @default.
• W4367316074 doi "https://doi.org/10.3390/foods12091814" @default.
• W4367316074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37174356" @default.
• W4367316074 hasPublicationYear "2023" @default.
• W4367316074 type Work @default.
• W4367316074 citedByCount "0" @default.
• W4367316074 crossrefType "journal-article" @default.

• next