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• W4367317059 endingPage "7984" @default.
• W4367317059 startingPage "7984" @default.
• W4367317059 abstract "Obesity causes systemic inflammation, hepatic and renal damage, as well as gut microbiota dysbiosis. Alternative vegetable sources rich in polyphenols are known to prevent or delay the progression of metabolic abnormalities during obesity. Vachellia farnesiana (VF) is a potent source of polyphenols with antioxidant and anti-inflammatory activities with potential anti-obesity effects. We performed an in vivo preventive or an interventional experimental study in mice and in vitro experiments with different cell types. In the preventive study, male C57BL/6 mice were fed with a Control diet, a high-fat diet, or a high-fat diet containing either 0.1% methyl gallate, 10% powdered VFP, or 0.5%, 1%, or 2% of a polyphenolic extract (PE) derived from VFP (Vachellia farnesiana pods) for 14 weeks. In the intervention study, two groups of mice were fed for 14 weeks with a high-fat diet and then one switched to a high-fat diet with 10% powdered VFP for ten additional weeks. In the in vitro studies, we evaluated the effect of a VFPE (Vachellia farnesiana polyphenolic extract) on glucose-stimulated insulin secretion in INS-1E cells or of naringenin or methyl gallate on mitochondrial activity in primary hepatocytes and C2C12 myotubes. VFP or a VFPE increased whole-body energy expenditure and mitochondrial activity in skeletal muscle; prevented insulin resistance, hepatic steatosis, and kidney damage; exerted immunomodulatory effects; and reshaped fecal gut microbiota composition in mice fed a high-fat diet. VFPE decreased insulin secretion in INS-1E cells, and its isolated compounds naringenin and methyl gallate increased mitochondrial activity in primary hepatocytes and C2C12 myotubes. In conclusion VFP or a VFPE prevented systemic inflammation, insulin resistance, and hepatic and renal damage in mice fed a high-fat diet associated with increased energy expenditure, improved mitochondrial function, and reduction in insulin secretion." @default.
• W4367317059 created "2023-04-29" @default.
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• W4367317059 date "2023-04-28" @default.
• W4367317059 modified "2023-10-18" @default.
• W4367317059 title "Vachellia farnesiana Pods or a Polyphenolic Extract Derived from Them Exert Immunomodulatory, Metabolic, Renoprotective, and Prebiotic Effects in Mice Fed a High-Fat Diet" @default.
• W4367317059 cites W1831301545 @default.
• W4367317059 cites W1947757275 @default.
• W4367317059 cites W1963960348 @default.
• W4367317059 cites W1974282645 @default.
• W4367317059 cites W1998642568 @default.
• W4367317059 cites W2007887164 @default.
• W4367317059 cites W2010397464 @default.
• W4367317059 cites W2043648447 @default.
• W4367317059 cites W2043870412 @default.
• W4367317059 cites W2044805997 @default.
• W4367317059 cites W2045333877 @default.
• W4367317059 cites W2058856567 @default.
• W4367317059 cites W2072482644 @default.
• W4367317059 cites W2078057461 @default.
• W4367317059 cites W2081689799 @default.
• W4367317059 cites W2092075198 @default.
• W4367317059 cites W2095142150 @default.
• W4367317059 cites W2095400574 @default.
• W4367317059 cites W2102369336 @default.
• W4367317059 cites W2113856541 @default.
• W4367317059 cites W2116468641 @default.
• W4367317059 cites W2128204933 @default.
• W4367317059 cites W2141789735 @default.
• W4367317059 cites W2162092846 @default.
• W4367317059 cites W2169386236 @default.
• W4367317059 cites W2169486907 @default.
• W4367317059 cites W2209871478 @default.
• W4367317059 cites W2285980052 @default.
• W4367317059 cites W2291294341 @default.
• W4367317059 cites W2321413400 @default.
• W4367317059 cites W2418778342 @default.
• W4367317059 cites W2419053103 @default.
• W4367317059 cites W2524785584 @default.
• W4367317059 cites W2530204217 @default.
• W4367317059 cites W2579921278 @default.
• W4367317059 cites W2605610684 @default.
• W4367317059 cites W2766925614 @default.
• W4367317059 cites W2790938080 @default.
• W4367317059 cites W2802369867 @default.
• W4367317059 cites W2884776261 @default.
• W4367317059 cites W2891725192 @default.
• W4367317059 cites W2898573672 @default.
• W4367317059 cites W2899941699 @default.
• W4367317059 cites W2905106220 @default.
• W4367317059 cites W2910652600 @default.
• W4367317059 cites W2912747073 @default.
• W4367317059 cites W2913202413 @default.
• W4367317059 cites W2929210839 @default.
• W4367317059 cites W2941131660 @default.
• W4367317059 cites W2988140105 @default.
• W4367317059 cites W3000322545 @default.
• W4367317059 cites W3000860815 @default.
• W4367317059 cites W3012643128 @default.
• W4367317059 cites W3036611464 @default.
• W4367317059 cites W3046555448 @default.
• W4367317059 cites W3087193143 @default.
• W4367317059 cites W3093401715 @default.
• W4367317059 cites W3118619864 @default.
• W4367317059 cites W3118979044 @default.
• W4367317059 cites W3132107011 @default.
• W4367317059 cites W3145114890 @default.
• W4367317059 cites W3164806748 @default.
• W4367317059 cites W3167131429 @default.
• W4367317059 cites W3207363757 @default.
• W4367317059 cites W4205748791 @default.
• W4367317059 cites W4221025084 @default.
• W4367317059 cites W4283218741 @default.
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• W4367317059 doi "https://doi.org/10.3390/ijms24097984" @default.
• W4367317059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37175691" @default.
• W4367317059 hasPublicationYear "2023" @default.
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