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- W4367319525 abstract "Pyrazolopyrimidine scaffold is one of the most favored heterocycles in drug discovery. Herein, a convenient and efficient protocol for the assembly of the hitherto unreported 4-(4-(dimethylamino)phenyl)-3-methyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-6-thiol (1) was disclosed. This approach comprises arylidene formation via a Knoevenagel condensation reaction between commercially available 3-methyl-1H-pyrazol-5(4H)-one and 4-(dimethylamino) benzaldehyde followed by a subsequent cyclization reaction with thiourea. Thereafter, a series of assorted fused and attached heterocycles originating from pyrazolo[3,4-d]pyrimidine derivative 1 was synthesized. Finally, the antibacterial activity of the novel assembled heterocycles was in vitro evaluated against diversified Gram-negative and Gram-positive bacteria. Various analytical and spectroscopic methods were utilized to confirm the proposed structures of the newly-synthesized compounds." @default.
- W4367319525 created "2023-04-29" @default.
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- W4367319525 date "2023-04-28" @default.
- W4367319525 modified "2023-09-23" @default.
- W4367319525 title "Pyrazolo[3,4‐<scp><i>d</i></scp>]pyrimidine‐based scaffolds as antibacterial agents: Synthetic strategies, reactions, and in vitro biological evaluation" @default.
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- W4367319525 doi "https://doi.org/10.1002/jhet.4656" @default.
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