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• W4367319539 endingPage "2530" @default.
• W4367319539 startingPage "2530" @default.
• W4367319539 abstract "Glioblastoma inevitably recurs, but no standard regimen has been established for treating this recurrent disease. Several reports claim that reoperative surgery can improve survival, but the effects of reoperation timing on survival have rarely been investigated. We, therefore, evaluated the relationship between reoperation timing and survival in recurrent GBM. A consecutive cohort of unselected patients (real-world data) from three neuro-oncology cancer centers was analyzed (a total of 109 patients). All patients underwent initial maximal safe resection followed by treatment according to the Stupp protocol. Those meeting the following criteria during progression were indicated for reoperation and were further analyzed in this study: (1) The tumor volume increased by >20-30% or a tumor was rediscovered after radiological disappearance; (2) The patient's clinical status was satisfactory (KS ≥ 70% and PS WHO ≤ gr. 2); (3) The tumor was localized without multifocality; (4) The minimum expected tumor volume reduction was above 80%. A univariate Cox regression analysis of postsurgical survival (PSS) revealed a statistically significant effect of reoperation on PSS from a threshold of 16 months after the first surgery. Cox regression models that stratified the Karnofsky score with age adjustment confirmed a statistically significant improvement in PSS for time-to-progression (TTP) thresholds of 22 and 24 months. The patient groups exhibiting the first recurrence at 22 and 24 months had better survival rates than those exhibiting earlier recurrences. For the 22-month group, the HR was 0.5 with a 95% CI of (0.27, 0.96) and a p-value of 0.036. For the 24-month group, the HR was 0.5 with a 95% CI of (0.25, 0.96) and a p-value of 0.039. Patients with the longest survival were also the best candidates for repeated surgery. Later recurrence of glioblastoma was associated with higher survival rates after reoperation." @default.
• W4367319539 created "2023-04-29" @default.
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• W4367319539 date "2023-04-28" @default.
• W4367319539 modified "2023-10-14" @default.
• W4367319539 title "Effects of Reoperation Timing on Survival among Recurrent Glioblastoma Patients: A Retrospective Multicentric Descriptive Study" @default.
• W4367319539 cites W1582145906 @default.
• W4367319539 cites W1624957772 @default.
• W4367319539 cites W1882450096 @default.
• W4367319539 cites W1887747927 @default.
• W4367319539 cites W1947532189 @default.
• W4367319539 cites W1987608721 @default.
• W4367319539 cites W1992253867 @default.
• W4367319539 cites W1996341366 @default.
• W4367319539 cites W2032113940 @default.
• W4367319539 cites W2042647718 @default.
• W4367319539 cites W2053717655 @default.
• W4367319539 cites W2054208824 @default.
• W4367319539 cites W2055764003 @default.
• W4367319539 cites W2071216849 @default.
• W4367319539 cites W2076421854 @default.
• W4367319539 cites W2076707297 @default.
• W4367319539 cites W2096287682 @default.
• W4367319539 cites W2098867019 @default.
• W4367319539 cites W2108119601 @default.
• W4367319539 cites W2109021590 @default.
• W4367319539 cites W2120079339 @default.
• W4367319539 cites W2121396361 @default.
• W4367319539 cites W2125157135 @default.
• W4367319539 cites W2132042712 @default.
• W4367319539 cites W2136785347 @default.
• W4367319539 cites W2141570482 @default.
• W4367319539 cites W2141699748 @default.
• W4367319539 cites W2143476979 @default.
• W4367319539 cites W2144897808 @default.
• W4367319539 cites W2147806499 @default.
• W4367319539 cites W2153384261 @default.
• W4367319539 cites W2158681922 @default.
• W4367319539 cites W2162328939 @default.
• W4367319539 cites W2162496354 @default.
• W4367319539 cites W2162709266 @default.
• W4367319539 cites W2163264715 @default.
• W4367319539 cites W2164705247 @default.
• W4367319539 cites W2165871546 @default.
• W4367319539 cites W2167709622 @default.
• W4367319539 cites W2185568816 @default.
• W4367319539 cites W2229790772 @default.
• W4367319539 cites W2272888082 @default.
• W4367319539 cites W2313882001 @default.
• W4367319539 cites W2366536035 @default.
• W4367319539 cites W2386703324 @default.
• W4367319539 cites W2511406084 @default.
• W4367319539 cites W2530870925 @default.
• W4367319539 cites W2555815408 @default.
• W4367319539 cites W2556288693 @default.
• W4367319539 cites W2561615462 @default.
• W4367319539 cites W2575948927 @default.
• W4367319539 cites W2604913157 @default.
• W4367319539 cites W2606034680 @default.
• W4367319539 cites W2606242457 @default.
• W4367319539 cites W2607482886 @default.
• W4367319539 cites W2618498448 @default.
• W4367319539 cites W2620216499 @default.
• W4367319539 cites W2731433442 @default.
• W4367319539 cites W2739325978 @default.
• W4367319539 cites W2755431391 @default.
• W4367319539 cites W2768674497 @default.
• W4367319539 cites W2771541152 @default.
• W4367319539 cites W2781633865 @default.
• W4367319539 cites W2782371148 @default.
• W4367319539 cites W2793297094 @default.
• W4367319539 cites W2793555954 @default.
• W4367319539 cites W2798231443 @default.
• W4367319539 cites W2895050596 @default.
• W4367319539 cites W2910721851 @default.
• W4367319539 cites W2913173828 @default.
• W4367319539 cites W2915397901 @default.
• W4367319539 cites W2921741526 @default.
• W4367319539 cites W2922687256 @default.
• W4367319539 cites W2939169454 @default.
• W4367319539 cites W2939765841 @default.
• W4367319539 cites W2964349316 @default.
• W4367319539 cites W3039867476 @default.
• W4367319539 cites W3083421441 @default.
• W4367319539 cites W3092540038 @default.
• W4367319539 cites W3129487631 @default.
• W4367319539 cites W3136555757 @default.

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