Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367320137> ?p ?o ?g. }
- W4367320137 endingPage "7946" @default.
- W4367320137 startingPage "7946" @default.
- W4367320137 abstract "Clear cell renal cell carcinoma (ccRCC) is a type of kidney cancer that arises from the cells lining the tubes of the kidney. The tumor immune microenvironment (TIME) of ccRCC is a complex interplay of various immune cells, cytokines, and signaling pathways. One of the critical features of the ccRCC TIME is the presence of infiltrating immune cells, including T cells, B cells, natural killer cells, dendritic cells, and myeloid-derived suppressor cells. Among these cells, CD8+ T cells are particularly important in controlling tumor growth by recognizing and killing cancer cells. However, the TIME of ccRCC is also characterized by an immunosuppressive environment that hinders the function of immune cells. Several mechanisms contribute to the immunosuppressive nature of the ccRCC TIME. For instance, ccRCC cells produce cytokines such as interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), which suppress immune cell activation and promote the differentiation of regulatory T cells (Tregs). Tregs, in turn, dampen the activity of effector T cells and promote tumor growth. In addition, ccRCC cells can express programmed death-ligand 1 (PD-L1), which interacts with the programmed cell death protein 1 (PD-1) receptor on T cells to inhibit their function. In addition, other immune checkpoint proteins, such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and lymphocyte activation gene 3 (LAG-3), also contribute to the immunosuppressive milieu of the ccRCC TIME. Finally, the hypoxic and nutrient-poor microenvironment of ccRCC can stimulate the production of immunosuppressive metabolites, such as adenosine and kynurenine, which further impair the function of immune cells. Understanding the complex interplay between tumor cells and the immune system in the ccRCC TIME is crucial for developing effective immunotherapies to treat this disease." @default.
- W4367320137 created "2023-04-29" @default.
- W4367320137 creator A5001582155 @default.
- W4367320137 creator A5027974294 @default.
- W4367320137 creator A5034010962 @default.
- W4367320137 creator A5039551292 @default.
- W4367320137 creator A5051906941 @default.
- W4367320137 creator A5071879294 @default.
- W4367320137 date "2023-04-27" @default.
- W4367320137 modified "2023-10-01" @default.
- W4367320137 title "The Tumor Immune Microenvironment in Clear Cell Renal Cell Carcinoma" @default.
- W4367320137 cites W1052483428 @default.
- W4367320137 cites W1179357147 @default.
- W4367320137 cites W1232974837 @default.
- W4367320137 cites W1538902372 @default.
- W4367320137 cites W1563409635 @default.
- W4367320137 cites W1630133385 @default.
- W4367320137 cites W1751758267 @default.
- W4367320137 cites W1935912749 @default.
- W4367320137 cites W1969963445 @default.
- W4367320137 cites W1994375251 @default.
- W4367320137 cites W1994993231 @default.
- W4367320137 cites W2004630197 @default.
- W4367320137 cites W2015415347 @default.
- W4367320137 cites W2042687451 @default.
- W4367320137 cites W2049491375 @default.
- W4367320137 cites W2066671159 @default.
- W4367320137 cites W2070855360 @default.
- W4367320137 cites W2094366129 @default.
- W4367320137 cites W2098902167 @default.
- W4367320137 cites W2117692326 @default.
- W4367320137 cites W2118618934 @default.
- W4367320137 cites W2129411754 @default.
- W4367320137 cites W2131860315 @default.
- W4367320137 cites W2147084913 @default.
- W4367320137 cites W2153238348 @default.
- W4367320137 cites W2166005929 @default.
- W4367320137 cites W2222086386 @default.
- W4367320137 cites W2234445408 @default.
- W4367320137 cites W2260056315 @default.
- W4367320137 cites W2412807977 @default.
- W4367320137 cites W2440755571 @default.
- W4367320137 cites W2471500324 @default.
- W4367320137 cites W2556766021 @default.
- W4367320137 cites W2560367415 @default.
- W4367320137 cites W2582388243 @default.
- W4367320137 cites W2589053981 @default.
- W4367320137 cites W2611919322 @default.
- W4367320137 cites W2617490000 @default.
- W4367320137 cites W2726542547 @default.
- W4367320137 cites W2740177870 @default.
- W4367320137 cites W2774416127 @default.
- W4367320137 cites W2792937256 @default.
- W4367320137 cites W2801270371 @default.
- W4367320137 cites W2801309958 @default.
- W4367320137 cites W2805302875 @default.
- W4367320137 cites W2884170377 @default.
- W4367320137 cites W2896467275 @default.
- W4367320137 cites W2897460617 @default.
- W4367320137 cites W2910857268 @default.
- W4367320137 cites W2913745075 @default.
- W4367320137 cites W2922310334 @default.
- W4367320137 cites W2951424976 @default.
- W4367320137 cites W2971657453 @default.
- W4367320137 cites W2974674959 @default.
- W4367320137 cites W2983881420 @default.
- W4367320137 cites W2999417355 @default.
- W4367320137 cites W3012628191 @default.
- W4367320137 cites W3045831978 @default.
- W4367320137 cites W3123032394 @default.
- W4367320137 cites W3127284279 @default.
- W4367320137 cites W3132298784 @default.
- W4367320137 cites W3134949580 @default.
- W4367320137 cites W3141640839 @default.
- W4367320137 cites W3153848664 @default.
- W4367320137 cites W3178932203 @default.
- W4367320137 cites W4206214161 @default.
- W4367320137 cites W4206722859 @default.
- W4367320137 cites W4210254696 @default.
- W4367320137 cites W4210899999 @default.
- W4367320137 cites W4211210519 @default.
- W4367320137 cites W4211225433 @default.
- W4367320137 cites W4225376778 @default.
- W4367320137 cites W4280607947 @default.
- W4367320137 cites W4287958717 @default.
- W4367320137 cites W4293043553 @default.
- W4367320137 cites W4306411150 @default.
- W4367320137 cites W4307423139 @default.
- W4367320137 doi "https://doi.org/10.3390/ijms24097946" @default.
- W4367320137 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37175653" @default.
- W4367320137 hasPublicationYear "2023" @default.
- W4367320137 type Work @default.
- W4367320137 citedByCount "1" @default.
- W4367320137 countsByYear W43673201372023 @default.
- W4367320137 crossrefType "journal-article" @default.
- W4367320137 hasAuthorship W4367320137A5001582155 @default.
- W4367320137 hasAuthorship W4367320137A5027974294 @default.
- W4367320137 hasAuthorship W4367320137A5034010962 @default.