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- W4367320570 abstract "目的： 探讨儿童肠道软斑病的临床病理学特征。 方法： 收集4例儿童肠道软斑病的临床病理资料，总结分析其临床及内镜特点、组织学、免疫组织化学及特殊染色的结果，并进行随访。 结果： 4例患儿年龄5~12岁，均有原发性免疫缺陷病基础，临床表现为腹痛、腹泻、血便等症状；部分伴反复发热、呼吸道感染、关节肿痛等症状；内镜下结直肠见多发隆起性、息肉样改变。肠镜活检标本组织学显示：隐窝扭曲、隐窝萎缩明显，间质慢性炎性细胞浸润，类似炎症性肠病改变，而隐窝脓肿少见，浆细胞数量没有增多；可见组织细胞聚集，其胞质丰富、淡红染，胞内外可见同心圆、靶环样的软斑小体。免疫组织化学示组织细胞CD68和CD163阳性，过碘酸雪夫染色软斑小体呈紫红色。4例行抗感染及原发病治疗，随访2~30个月，肠道症状均明显改善。 结论： 儿童肠道软斑病多有免疫缺陷或免疫低下的病史，内镜下以及活检病理特点容易与炎症性肠病等混淆，了解其临床病理特征有助于鉴别诊断。." @default.
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- W4367320570 date "2023-05-08" @default.
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- W4367320570 title "[Clinicopathological analysis of intestinal malakoplakia in children]." @default.
- W4367320570 doi "https://doi.org/10.3760/cma.j.cn112151-20220801-00667" @default.
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