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- W4367321462 abstract "Monoclonal antibody products are an increasing portion of novel drug approvals. The labeling of initial drug approvals frequently involves body-size-based rather than fixed-dose administration regimens for adults without clear rationale for doing so. This presents challenges when prescribing these products for patients with extremes of body habitus who constitute a small portion of enrollment in pre-approval investigations. Fixed-dose regimens allow for standardized preparation with the potential to reduce the risk of calculation errors, drug waste, and make home administration more practical. Fixed-dose rather than body-size-based monoclonal antibody regimens should serve as the initial approach in early phase 1 clinical trials." @default.
- W4367321462 created "2023-04-29" @default.
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- W4367321462 date "2023-04-27" @default.
- W4367321462 modified "2023-09-25" @default.
- W4367321462 title "Fixed Versus Body-Sized-Based Dosing of Monoclonal Antibodies" @default.
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- W4367321462 doi "https://doi.org/10.1177/10600280231170650" @default.
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