FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367321734> ?p ?o ?g. }

• W4367321734 endingPage "107176" @default.
• W4367321734 startingPage "107176" @default.
• W4367321734 abstract "Intravascular hemolysis (IVH) occurs in numerous inherited and acquired disorders, including sickle cell disease (SCD), malaria and sepsis. These diseases display unique symptoms, but often share complications, such as vasomotor dysfunction and pulmonary hypertension. Consequently, in vivo models are needed to study the effects of continuous intravascular hemolytic processes, independently of the molecular alteration or extrinsic factor that leads to erythrocyte destruction. We gave twice-weekly low-dose phenylhydrazine (LDPHZ) to C57BL/6 J mice for 4 weeks, and measured parameters indicative of anemia, hemoglobin-clearance pathways, inflammation and iron turnover, comparing these to those of a murine model of SCD, which displays associated IVH. LDPHZ administration provoked discreet anemia in mice and significant reticulocytosis, in association with hemoglobin/heme-clearance pathway protein depletion. Mice subjected to chronic hemolysis displayed elevated leukocyte counts and plasma levels of interleukin (IL)-1β, TNF-α, IL-6, soluble ICAM-1, endothelin-1 and anti-inflammatory IL-10, closely emulating alterations indicative of systemic inflammatory and endothelial activation in SCD, and confirming chronic IVH in itself as a serious complication. Discreet accelerations in hepatic and splenic iron turnover also occurred in LDPHZ mice, without alterations in liver damage markers. Examining the effects of two therapies on hemolysis-induced inflammation, the administration of hydroxyurea (and to a lesser extent, l-glutamine) significantly abrogated hemolytic inflammation in mice, without apparent inhibition of hemolysis. In conclusion, the isolation of chronic IVH, a common disease mechanism, using this model, may allow the study of hemolysis-specific sequelae at the cellular and systemic level, and the investigation of candidate agents that could potentially counter hemolytic inflammation." @default.
• W4367321734 created "2023-04-29" @default.
• W4367321734 creator A5000536583 @default.
• W4367321734 creator A5024133000 @default.
• W4367321734 creator A5050058477 @default.
• W4367321734 creator A5067515209 @default.
• W4367321734 creator A5067713063 @default.
• W4367321734 creator A5084195232 @default.
• W4367321734 creator A5086831315 @default.
• W4367321734 date "2023-06-01" @default.
• W4367321734 modified "2023-10-16" @default.
• W4367321734 title "Molecular and cellular effects of in vivo chronic intravascular hemolysis and anti-inflammatory therapeutic approaches" @default.
• W4367321734 cites W1563283093 @default.
• W4367321734 cites W1984887661 @default.
• W4367321734 cites W1995879313 @default.
• W4367321734 cites W2012747049 @default.
• W4367321734 cites W2014260661 @default.
• W4367321734 cites W2026254409 @default.
• W4367321734 cites W2032628053 @default.
• W4367321734 cites W2049129790 @default.
• W4367321734 cites W2051759508 @default.
• W4367321734 cites W2055848370 @default.
• W4367321734 cites W2057467676 @default.
• W4367321734 cites W2071061616 @default.
• W4367321734 cites W2080454544 @default.
• W4367321734 cites W2082679209 @default.
• W4367321734 cites W2088142457 @default.
• W4367321734 cites W2089734870 @default.
• W4367321734 cites W2095449018 @default.
• W4367321734 cites W2100360129 @default.
• W4367321734 cites W2131868847 @default.
• W4367321734 cites W2132669112 @default.
• W4367321734 cites W2133831383 @default.
• W4367321734 cites W2136049237 @default.
• W4367321734 cites W2143009142 @default.
• W4367321734 cites W2146650664 @default.
• W4367321734 cites W2148765840 @default.
• W4367321734 cites W2150027863 @default.
• W4367321734 cites W2166262520 @default.
• W4367321734 cites W2169450299 @default.
• W4367321734 cites W2178377783 @default.
• W4367321734 cites W2259761062 @default.
• W4367321734 cites W2322453619 @default.
• W4367321734 cites W2400058471 @default.
• W4367321734 cites W2412746466 @default.
• W4367321734 cites W2416922045 @default.
• W4367321734 cites W2529894541 @default.
• W4367321734 cites W2592339311 @default.
• W4367321734 cites W2604429438 @default.
• W4367321734 cites W2605241186 @default.
• W4367321734 cites W2766690961 @default.
• W4367321734 cites W2767498689 @default.
• W4367321734 cites W2793121068 @default.
• W4367321734 cites W2794850401 @default.
• W4367321734 cites W2803098705 @default.
• W4367321734 cites W2883955692 @default.
• W4367321734 cites W2889136172 @default.
• W4367321734 cites W2916731820 @default.
• W4367321734 cites W2947314253 @default.
• W4367321734 cites W2952786688 @default.
• W4367321734 cites W3003559479 @default.
• W4367321734 cites W3027891516 @default.
• W4367321734 cites W3038723325 @default.
• W4367321734 cites W3046362022 @default.
• W4367321734 cites W3082123477 @default.
• W4367321734 cites W3195018996 @default.
• W4367321734 cites W3204983369 @default.
• W4367321734 cites W41094349 @default.
• W4367321734 cites W4205889040 @default.
• W4367321734 cites W4210339565 @default.
• W4367321734 cites W4241694836 @default.
• W4367321734 cites W4293583423 @default.
• W4367321734 cites W2614002123 @default.
• W4367321734 doi "https://doi.org/10.1016/j.vph.2023.107176" @default.
• W4367321734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37116732" @default.
• W4367321734 hasPublicationYear "2023" @default.
• W4367321734 type Work @default.
• W4367321734 citedByCount "0" @default.
• W4367321734 crossrefType "journal-article" @default.
• W4367321734 hasAuthorship W4367321734A5000536583 @default.
• W4367321734 hasAuthorship W4367321734A5024133000 @default.
• W4367321734 hasAuthorship W4367321734A5050058477 @default.
• W4367321734 hasAuthorship W4367321734A5067515209 @default.
• W4367321734 hasAuthorship W4367321734A5067713063 @default.
• W4367321734 hasAuthorship W4367321734A5084195232 @default.
• W4367321734 hasAuthorship W4367321734A5086831315 @default.
• W4367321734 hasConcept C126322002 @default.
• W4367321734 hasConcept C150903083 @default.
• W4367321734 hasConcept C203014093 @default.
• W4367321734 hasConcept C207001950 @default.
• W4367321734 hasConcept C2776914184 @default.
• W4367321734 hasConcept C2777799521 @default.
• W4367321734 hasConcept C2778248108 @default.
• W4367321734 hasConcept C2778384902 @default.
• W4367321734 hasConcept C2779902561 @default.
• W4367321734 hasConcept C2780972559 @default.
• W4367321734 hasConcept C71924100 @default.
• W4367321734 hasConcept C86803240 @default.

• next