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• W4367322541 abstract "Regulatory T cells (Tregs) are among the most abundant suppressive cells, which infiltrate and accumulate in the tumor microenvironment, leading to tumor escape by inducing anergy and immunosuppression. Their presence has been correlated with tumor progression, invasiveness and metastasis. Targeting tumor-associated Tregs is an effective addition to current immunotherapy approaches, but it may also trigger autoimmune diseases. The major limitation of current therapies targeting Tregs in the tumor microenvironment is the lack of selective targets. Tumor-infiltrating Tregs express high levels of cell surface molecules associated with T-cell activation, such as CTLA4, PD-1, LAG3, TIGIT, ICOS, and TNF receptor superfamily members including 4-1BB, OX40, and GITR. Targeting these molecules often attribute to concurrent depletion of antitumor effector T-cell populations. Therefore, novel approaches need to improve the specificity of targeting Tregs in the tumor microenvironment without affecting peripheral Tregs and effector T cells. In this review, we discuss the immunosuppressive mechanisms of tumor-infiltrating Tregs and the status of antibody-based immunotherapies targeting Tregs." @default.
• W4367322541 created "2023-04-29" @default.
• W4367322541 creator A5006044998 @default.
• W4367322541 creator A5014652724 @default.
• W4367322541 creator A5060060173 @default.
• W4367322541 creator A5061706893 @default.
• W4367322541 creator A5073076889 @default.
• W4367322541 creator A5074158503 @default.
• W4367322541 date "2023-04-27" @default.
• W4367322541 modified "2023-09-26" @default.
• W4367322541 title "Antibody-based cancer immunotherapy by targeting regulatory T cells" @default.
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