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• W4367330108 endingPage "1338" @default.
• W4367330108 startingPage "1329" @default.
• W4367330108 abstract "Background & Aims: Abdominal symptoms in the absence of mucosal abnormalities are features of both the irritable bowel syndrome (IBS) and latent/potential celiac disease (cd). To identify a possible subgroup of IBS patients with latent/potential cd, surrogate markers of cd were investigated in IBS patients. Methods: IBS patients suffering from diarrhea (n = 102), and patients with active cd (n = 10), treated cd (n = 26), and latent cd (n = 5) were included in the study. We measured serum immunoglobulin (Ig) A against gliadin and tissue-transglutaminase, and IgA and IgM against gliadin, tissue-transglutaminase (intestinal cd–associated antibodies), and the dietary proteins β-lactoglobulin and ovalbumin in duodenal aspirate by enzyme-linked immunosorbent assay. Intraepithelial lymphocytes (IELs) were counted in histology sections, and the expression of HLA-DQ2 (A1*0501/B1*0201) was investigated by polymerase chain reaction. In 26 IBS patients, the effect of 6 months of gluten withdrawal was examined. Results: Most cd patients expressed HLA-DQ2 and had increased intestinal cd–associated antibodies, whereas cd-associated serum IgA and IEL counts were increased in active cd in contrast to treated or latent cd. In IBS patients, 35% were HLA-DQ2–positive, 23% had increased IEL counts, and 0% and 30% had increased cd-associated antibodies in serum and duodenal aspirate, respectively. Furthermore, stool frequency and intestinal IgA decreased significantly under a gluten-free diet in the subgroups of HLA-DQ2–positive and intestinal antibody–positive IBS patients when compared with IBS patients without these markers. Conclusions: HLA-DQ2 expression and increased intestinal cd–associated antibodies are markers that can identify latent/potential cd in a subgroup of IBS patients who consequently appear to profit from a gluten-free diet.GASTROENTEROLOGY 2001;121:1329-1338" @default.
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• W4367330108 date "2001-12-01" @default.
• W4367330108 modified "2023-10-17" @default.
• W4367330108 title "Celiac disease–like abnormalities in a subgroup of patients with irritable bowel syndrome" @default.
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• W4367330108 doi "https://doi.org/10.1053/gast.2001.29572" @default.
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