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- W4367363114 abstract "SUMMARY Ezetimibe is a novel cholesterol absorption inhibitor that blocks intestinal absorption of dietary and biliary cholesterol. Data from 1719 patients who participated in two multicentre, double‐blind studies of ezetimibe were pooled to evaluate the drug's efficacy and safety in patients with primary hypercholesterolaemia. Following dietary stabilisation, a two‐ to 12‐week washout period, and a four‐week, single‐blind, placebo lead‐in period, patients were randomised to ezetimibe 10 mg or placebo once daily in the morning for 12 consecutive weeks. The primary efficacy endpoint was percent reduction in plasma low‐density lipoprotein (LDL)‐cholesterol from baseline at endpoint. Ezetimibe reduced LDL‐cholesterol by a mean of 18.2% compared with an increase of 0.9% with placebo (p<0.01) and resulted in favourable, statistically significant changes in HDL‐cholesterol, triglycerides and apo B. The response to ezetimibe was consistent across all subgroups analysed. Ezetimibe was well tolerated, with a safety profile similar to placebo. ( Int J Clin Pract 2003; 57(5): 363–368)" @default.
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- W4367363114 date "2003-06-01" @default.
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- W4367363114 title "EVALUATION OF THE EFFICACY, SAFETY, AND TOLERABILITY OF EZETIMIBE IN PRIMARY HYPERCHOLESTEROLAEMIA: A POOLED ANALYSIS FROM TWO CONTROLLED PHASE III CLINICAL STUDIES" @default.
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- W4367363114 doi "https://doi.org/10.1111/j.1742-1241.2003.tb10508.x" @default.
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