Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367366191> ?p ?o ?g. }
- W4367366191 abstract "Abstract Diagnostic of radiation effects can be obtained within hours from delivery relying on spectroscopic detection of cell metabolite concentrations. Clinical and pre-clinical studies show that radiation delivery with elevated dose-rates can achieve tumor suppression while minimizing toxicity to surrounding areas. Diagnostic biomarkers detected on short timescales are needed to orient high dose-rate radiation delivery. We have designed an 1 H magnetic resonance approach to observe metabolite concentrations, in particular Choline, Creatine, and Lactate, in order to detect radiation dose and dose-rate effects within hours from radiation delivery. The results of our metabolic profiling method in glioblastoma cells are consistent with observations from clinical studies guided by magnetic resonance spectroscopy for radiotherapy of head tumors. At 5 Gy/min we have observed increases in lactate concentrations and decreases in [Cho]/[Cr] ratios at increasing radiation doses. An increase of the radiation dose-rate to 35 Gy/min is correlated with an increase of [Cho]/[Cr] consistent with a reduction in radiation-induced oxidative effects at high dose-rates. The observed biomarkers can be translated for radiation pulse sequences optimization. One Sentence Summary Magnetic resonance biomarkers to monitor biological effectiveness within hours after radiation delivery can be optimized for glioblastoma cells and are of potential use for the design of radiotherapy with high dose-rates." @default.
- W4367366191 created "2023-04-30" @default.
- W4367366191 creator A5000028461 @default.
- W4367366191 creator A5016290722 @default.
- W4367366191 creator A5019100028 @default.
- W4367366191 creator A5031771968 @default.
- W4367366191 creator A5041443456 @default.
- W4367366191 creator A5043139328 @default.
- W4367366191 creator A5056868129 @default.
- W4367366191 creator A5057090176 @default.
- W4367366191 creator A5064874089 @default.
- W4367366191 creator A5065941982 @default.
- W4367366191 creator A5069771048 @default.
- W4367366191 creator A5081079456 @default.
- W4367366191 creator A5082807518 @default.
- W4367366191 creator A5085345225 @default.
- W4367366191 date "2023-04-29" @default.
- W4367366191 modified "2023-10-18" @default.
- W4367366191 title "Magnetic resonance biomarkers for timely diagnostic of radiation dose-rate effects" @default.
- W4367366191 cites W1551372829 @default.
- W4367366191 cites W1978632796 @default.
- W4367366191 cites W2035443994 @default.
- W4367366191 cites W2058648933 @default.
- W4367366191 cites W2059900570 @default.
- W4367366191 cites W2060782947 @default.
- W4367366191 cites W2072905431 @default.
- W4367366191 cites W2076755375 @default.
- W4367366191 cites W2081935151 @default.
- W4367366191 cites W2162578848 @default.
- W4367366191 cites W2509964283 @default.
- W4367366191 cites W2902352501 @default.
- W4367366191 cites W2958174590 @default.
- W4367366191 cites W2990428083 @default.
- W4367366191 cites W3026859573 @default.
- W4367366191 cites W3036793865 @default.
- W4367366191 cites W3145004192 @default.
- W4367366191 cites W3163682901 @default.
- W4367366191 cites W3165581215 @default.
- W4367366191 cites W4210586081 @default.
- W4367366191 cites W4211210257 @default.
- W4367366191 cites W4303510347 @default.
- W4367366191 cites W4307773742 @default.
- W4367366191 doi "https://doi.org/10.1101/2023.04.28.538667" @default.
- W4367366191 hasPublicationYear "2023" @default.
- W4367366191 type Work @default.
- W4367366191 citedByCount "0" @default.
- W4367366191 crossrefType "posted-content" @default.
- W4367366191 hasAuthorship W4367366191A5000028461 @default.
- W4367366191 hasAuthorship W4367366191A5016290722 @default.
- W4367366191 hasAuthorship W4367366191A5019100028 @default.
- W4367366191 hasAuthorship W4367366191A5031771968 @default.
- W4367366191 hasAuthorship W4367366191A5041443456 @default.
- W4367366191 hasAuthorship W4367366191A5043139328 @default.
- W4367366191 hasAuthorship W4367366191A5056868129 @default.
- W4367366191 hasAuthorship W4367366191A5057090176 @default.
- W4367366191 hasAuthorship W4367366191A5064874089 @default.
- W4367366191 hasAuthorship W4367366191A5065941982 @default.
- W4367366191 hasAuthorship W4367366191A5069771048 @default.
- W4367366191 hasAuthorship W4367366191A5081079456 @default.
- W4367366191 hasAuthorship W4367366191A5082807518 @default.
- W4367366191 hasAuthorship W4367366191A5085345225 @default.
- W4367366191 hasBestOaLocation W43673661911 @default.
- W4367366191 hasConcept C111337013 @default.
- W4367366191 hasConcept C120665830 @default.
- W4367366191 hasConcept C121332964 @default.
- W4367366191 hasConcept C126322002 @default.
- W4367366191 hasConcept C126838900 @default.
- W4367366191 hasConcept C143409427 @default.
- W4367366191 hasConcept C153385146 @default.
- W4367366191 hasConcept C18231593 @default.
- W4367366191 hasConcept C185544564 @default.
- W4367366191 hasConcept C185592680 @default.
- W4367366191 hasConcept C2777477808 @default.
- W4367366191 hasConcept C2779896295 @default.
- W4367366191 hasConcept C2987700449 @default.
- W4367366191 hasConcept C2989005 @default.
- W4367366191 hasConcept C509974204 @default.
- W4367366191 hasConcept C71924100 @default.
- W4367366191 hasConceptScore W4367366191C111337013 @default.
- W4367366191 hasConceptScore W4367366191C120665830 @default.
- W4367366191 hasConceptScore W4367366191C121332964 @default.
- W4367366191 hasConceptScore W4367366191C126322002 @default.
- W4367366191 hasConceptScore W4367366191C126838900 @default.
- W4367366191 hasConceptScore W4367366191C143409427 @default.
- W4367366191 hasConceptScore W4367366191C153385146 @default.
- W4367366191 hasConceptScore W4367366191C18231593 @default.
- W4367366191 hasConceptScore W4367366191C185544564 @default.
- W4367366191 hasConceptScore W4367366191C185592680 @default.
- W4367366191 hasConceptScore W4367366191C2777477808 @default.
- W4367366191 hasConceptScore W4367366191C2779896295 @default.
- W4367366191 hasConceptScore W4367366191C2987700449 @default.
- W4367366191 hasConceptScore W4367366191C2989005 @default.
- W4367366191 hasConceptScore W4367366191C509974204 @default.
- W4367366191 hasConceptScore W4367366191C71924100 @default.
- W4367366191 hasLocation W43673661911 @default.
- W4367366191 hasOpenAccess W4367366191 @default.
- W4367366191 hasPrimaryLocation W43673661911 @default.
- W4367366191 hasRelatedWork W110753632 @default.
- W4367366191 hasRelatedWork W1975792727 @default.
- W4367366191 hasRelatedWork W1998787884 @default.