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- W4367367377 endingPage "1801" @default.
- W4367367377 startingPage "1786" @default.
- W4367367377 abstract "Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant disease with a 5-year survival rate of <10%. Aberrant activation or elevated expression of the tyrosine kinase c-SRC (SRC) is frequently observed in PDAC and is associated with a poor prognosis. Preclinical studies have revealed a multifaceted role for SRC activation in PDAC, including promoting chronic inflammation, tumor cell proliferation and survival, cancer cell stemness, desmoplasia, hypoxia, angiogenesis, invasion, metastasis, and drug resistance. Strategies to inhibit SRC signaling include suppressing its catalytic activity, inhibiting protein stability, or by interfering with signaling components of the SRC signaling pathway including suppressing protein interactions of SRC. In this review, we discuss the molecular and immunological mechanisms by which aberrant SRC activity promotes PDAC tumorigenesis. We also provide a comprehensive update of SRC inhibitors in the clinic, and discuss the clinical challenges associated with targeting SRC in pancreatic cancer." @default.
- W4367367377 created "2023-04-30" @default.
- W4367367377 creator A5031554487 @default.
- W4367367377 creator A5067242663 @default.
- W4367367377 date "2023-04-29" @default.
- W4367367377 modified "2023-10-18" @default.
- W4367367377 title "Functional roles of SRC signaling in pancreatic cancer: Recent insights provide novel therapeutic opportunities" @default.
- W4367367377 cites W1540012817 @default.
- W4367367377 cites W1571287379 @default.
- W4367367377 cites W1828225209 @default.
- W4367367377 cites W1857349425 @default.
- W4367367377 cites W1863396779 @default.
- W4367367377 cites W1874830478 @default.
- W4367367377 cites W1934287581 @default.
- W4367367377 cites W1965095341 @default.
- W4367367377 cites W1966282229 @default.
- W4367367377 cites W1967324554 @default.
- W4367367377 cites W1972035895 @default.
- W4367367377 cites W1972823610 @default.
- W4367367377 cites W1974517994 @default.
- W4367367377 cites W1975186629 @default.
- W4367367377 cites W1975522056 @default.
- W4367367377 cites W1976933694 @default.
- W4367367377 cites W1977681992 @default.
- W4367367377 cites W1977748809 @default.
- W4367367377 cites W1979452780 @default.
- W4367367377 cites W1982536372 @default.
- W4367367377 cites W1982853447 @default.
- W4367367377 cites W1984283577 @default.
- W4367367377 cites W1985092878 @default.
- W4367367377 cites W1985801107 @default.
- W4367367377 cites W1987294326 @default.
- W4367367377 cites W1987313243 @default.
- W4367367377 cites W1988622995 @default.
- W4367367377 cites W1992831404 @default.
- W4367367377 cites W1992880310 @default.
- W4367367377 cites W1992954790 @default.
- W4367367377 cites W1992995822 @default.
- W4367367377 cites W1994151176 @default.
- W4367367377 cites W1996537616 @default.
- W4367367377 cites W1996873142 @default.
- W4367367377 cites W1999609185 @default.
- W4367367377 cites W2000170431 @default.
- W4367367377 cites W2000294777 @default.
- W4367367377 cites W2000868207 @default.
- W4367367377 cites W2001737550 @default.
- W4367367377 cites W2002121555 @default.
- W4367367377 cites W2003405179 @default.
- W4367367377 cites W2003760554 @default.
- W4367367377 cites W2004771750 @default.
- W4367367377 cites W2004792969 @default.
- W4367367377 cites W2006899675 @default.
- W4367367377 cites W2007503777 @default.
- W4367367377 cites W2008351137 @default.
- W4367367377 cites W2009222563 @default.
- W4367367377 cites W2011707243 @default.
- W4367367377 cites W2012122601 @default.
- W4367367377 cites W2012347139 @default.
- W4367367377 cites W2012564445 @default.
- W4367367377 cites W2012604362 @default.
- W4367367377 cites W2014058353 @default.
- W4367367377 cites W2017362306 @default.
- W4367367377 cites W2018982382 @default.
- W4367367377 cites W2022847745 @default.
- W4367367377 cites W2026184890 @default.
- W4367367377 cites W2026279585 @default.
- W4367367377 cites W2026299485 @default.
- W4367367377 cites W2028638661 @default.
- W4367367377 cites W2029790299 @default.
- W4367367377 cites W2032062053 @default.
- W4367367377 cites W2032116260 @default.
- W4367367377 cites W2032157282 @default.
- W4367367377 cites W2032674547 @default.
- W4367367377 cites W2033526561 @default.
- W4367367377 cites W2033998652 @default.
- W4367367377 cites W2035183057 @default.
- W4367367377 cites W2036118441 @default.
- W4367367377 cites W2036988959 @default.
- W4367367377 cites W2038126788 @default.
- W4367367377 cites W2039225116 @default.
- W4367367377 cites W2044423100 @default.
- W4367367377 cites W2045394733 @default.
- W4367367377 cites W2047528221 @default.
- W4367367377 cites W2049953991 @default.
- W4367367377 cites W2050973237 @default.
- W4367367377 cites W2052063298 @default.
- W4367367377 cites W2052814975 @default.
- W4367367377 cites W2053298425 @default.
- W4367367377 cites W2054466658 @default.
- W4367367377 cites W2055345604 @default.
- W4367367377 cites W2057612230 @default.
- W4367367377 cites W2057687275 @default.
- W4367367377 cites W2058301168 @default.
- W4367367377 cites W2059437590 @default.
- W4367367377 cites W2063055656 @default.
- W4367367377 cites W2065033398 @default.
- W4367367377 cites W2065429233 @default.
- W4367367377 cites W2066254363 @default.