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- W4367368194 abstract "Abstract The phenomenon of bifurcation in disease transmission models has been observed in a number of epidemiological models. The consequence of bifurcation is that the classical requirement of the reproduction number being less than unity becomes only a necessary, but not sufficient, for disease elimination. This paper addresses the problem of finding the causes of bifurcation in standard deterministic models for the spread of HBV diseases with non-Cytolytic cure processes on infected liver and blood cells. The model contains logistic growth of healthy liver and blood cells and non -Cytolytic cure processes of infected cells. I have got that the model exhibits back ward and forward bifurcations with some conditions. The existence of a backward bifurcation is an interesting artifact since this means that the disease cannot be eradicated by simply reducing the value of the basic reproduction number $${R}_{0}$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:msub> <mml:mi>R</mml:mi> <mml:mn>0</mml:mn> </mml:msub> </mml:math> below 1.This can have important implications on drug therapy protocols, since it sheds light on possible control mechanisms for disease eradication." @default.
- W4367368194 created "2023-04-30" @default.
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- W4367368194 date "2023-04-29" @default.
- W4367368194 modified "2023-09-30" @default.
- W4367368194 title "Bifurcation analysis of hepatitis B virus with non-cytolytic cure process on infected liver and blood cells" @default.
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- W4367368194 doi "https://doi.org/10.1038/s41598-023-27468-9" @default.
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