Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367368259> ?p ?o ?g. }
- W4367368259 abstract "mTOR complex 2 (mTORC2) has been implicated as a key regulator of glioblastoma cell migration. However, the roles of mTORC2 in the migrational control process have not been entirely elucidated. Here, we elaborate that active mTORC2 is crucial for GBM cell motility. Inhibition of mTORC2 impaired cell movement and negatively affected microfilament and microtubule functions. We also aimed to characterize important players involved in the regulation of cell migration and other mTORC2-mediated cellular processes in GBM cells. Therefore, we quantitatively characterized the alteration of the mTORC2 interactome under selective conditions using affinity purification-mass spectrometry in glioblastoma. We demonstrated that changes in cell migration ability specifically altered mTORC2-associated proteins. GSN was identified as one of the most dynamic proteins. The mTORC2-GSN linkage was mostly highlighted in high-grade glioma cells, connecting functional mTORC2 to multiple proteins responsible for directional cell movement in GBM. Loss of GSN disconnected mTORC2 from numerous cytoskeletal proteins and affected the membrane localization of mTORC2. In addition, we reported 86 stable mTORC2-interacting proteins involved in diverse molecular functions, predominantly cytoskeletal remodeling, in GBM. Our findings might help expand future opportunities for predicting the highly migratory phenotype of brain cancers in clinical investigations." @default.
- W4367368259 created "2023-04-30" @default.
- W4367368259 creator A5003299197 @default.
- W4367368259 creator A5010030248 @default.
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- W4367368259 creator A5062497334 @default.
- W4367368259 creator A5082045334 @default.
- W4367368259 date "2023-04-29" @default.
- W4367368259 modified "2023-09-25" @default.
- W4367368259 title "mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin" @default.
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