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• W4367393409 abstract "Abstract Background Polycyclic aromatic hydrocarbon (PAH) contamination has been a worldwide environmental issue because of its impact on ecosystems and human health. Biodegradation plays an important role in PAH removal in natural environments. To date, many PAH-degrading strains and degradation genes have been reported. However, a comprehensive PAH-degrading gene database is still lacking, hindering a deep understanding of PAH degraders in the era of big data. Furthermore, the relationships between the PAH-catabolic genotype and phenotype remain unclear. Results Here, we established a bacterial PAH-degrading gene database and explored PAH biodegradation capability via a genome-function relationship approach. The investigation of functional genes in the experimentally verified PAH degraders indicated that genes encoding hydratase-aldolase could serve as a biomarker for preliminarily identifying potential degraders. Additionally, a genome-centric interpretation of PAH-degrading genes was performed in the public genome database, demonstrating that they were ubiquitous in Proteobacteria and Actinobacteria . Meanwhile, the global phylogenetic distribution was generally consistent with the culture-based evidence. Notably, a few strains affiliated with the genera without any previously known PAH degraders ( Hyphomonas , Hoeflea , Henriciella , Saccharomonospora , Sciscionella , Tepidiphilus , and Xenophilus ) also bore a complete PAH-catabolic gene cluster, implying their potential of PAH biodegradation. Moreover, a random forest analysis was applied to predict the PAH-degrading trait in the complete genome database, revealing 28 newly predicted PAH degraders, of which nine strains encoded a complete PAH-catabolic pathway. Conclusions Our results established a comprehensive PAH-degrading gene database and a genome-function relationship approach, which revealed several potential novel PAH-degrader lineages. Importantly, this genome-centric and function-oriented approach can overcome the bottleneck of conventional cultivation-based biodegradation research and substantially expand our current knowledge on the potential degraders of environmental pollutants." @default.
• W4367393409 created "2023-04-30" @default.
• W4367393409 creator A5012097815 @default.
• W4367393409 creator A5043786511 @default.
• W4367393409 creator A5047365117 @default.
• W4367393409 creator A5082177004 @default.
• W4367393409 date "2023-04-30" @default.
• W4367393409 modified "2023-10-09" @default.
• W4367393409 title "Polycyclic aromatic hydrocarbon (PAH) biodegradation capacity revealed by a genome-function relationship approach" @default.
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• W4367393409 doi "https://doi.org/10.1186/s40793-023-00497-7" @default.
• W4367393409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37122013" @default.
• W4367393409 hasPublicationYear "2023" @default.

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