Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367393784> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4367393784 abstract "Background: Microbiome-targeted treatments have been investigated in atopic dermatitis (AD). We aimed to investigate the use of probiotic Lactococcus lactis lysate cream in AD. Methods: 13 patients with mild-to-moderate AD were treated with differently concentrated probiotic creams (3%, 10% and 30%) or placebo cream for 4 weeks. Disease severity (EASI, IGA), epidermal barrier function (TEWL) and patient-reported impact (DLQI, POEM, ADCT, pruritus and sleep disturbance VAS) were measured at baseline, 4 and 8 weeks. Comprehensive clinical data and laboratory values (blood eosinophil count, total serum IgE-levels and specific IgEs to aeroallergens) were obtained. Results: Comparison of the treatment groups showed no clear differences regarding AD severity (EASI, p=0.76, CI: 0.65-1.00), epidermal barrier dysfunction (TEWL, p=0.37, CI: 0.19-0.73) or patient-reported impact (DLQI, p=0.76, CI: 0.65-1.00; POEM, p=0.76, CI: 0.35-0.88; ADCT, p=0.72, CI: 0.65-1.00; pruritus VAS 0.67, CI: 0.55-1.00; sleep disturbance VAS, p=1.00, CI: 0.79-1.00) between different probiotic lysate concentrations and placebo. The probiotic lysate cream was well tolerated and there were no significant adverse effects. Limitations were a small and heterogenous patient groups and a relatively short follow-up with no evaluation of long-term effects. Conclusions: Topical probiotic L. lactis lysate cream showed no clear differences between the tratment groups in mild-to-moderate AD. Although topical probiotics have been reported effective in a limited number of studies, more placebo-controlled clinical studies are needed to explore their potential role in the treatment of AD." @default.
- W4367393784 created "2023-04-30" @default.
- W4367393784 creator A5017063851 @default.
- W4367393784 creator A5022501254 @default.
- W4367393784 creator A5048150526 @default.
- W4367393784 creator A5069472906 @default.
- W4367393784 date "2023-04-29" @default.
- W4367393784 modified "2023-10-16" @default.
- W4367393784 title "Treatment of atopic dermatitis with probiotic L. lactis lysate - A double-blinded, placebo-controlled pilot study" @default.
- W4367393784 doi "https://doi.org/10.22541/au.168274264.45913900/v1" @default.
- W4367393784 hasPublicationYear "2023" @default.
- W4367393784 type Work @default.
- W4367393784 citedByCount "0" @default.
- W4367393784 crossrefType "posted-content" @default.
- W4367393784 hasAuthorship W4367393784A5017063851 @default.
- W4367393784 hasAuthorship W4367393784A5022501254 @default.
- W4367393784 hasAuthorship W4367393784A5048150526 @default.
- W4367393784 hasAuthorship W4367393784A5069472906 @default.
- W4367393784 hasBestOaLocation W43673937841 @default.
- W4367393784 hasConcept C126322002 @default.
- W4367393784 hasConcept C142724271 @default.
- W4367393784 hasConcept C16005928 @default.
- W4367393784 hasConcept C197934379 @default.
- W4367393784 hasConcept C204787440 @default.
- W4367393784 hasConcept C27081682 @default.
- W4367393784 hasConcept C2778329239 @default.
- W4367393784 hasConcept C2778370115 @default.
- W4367393784 hasConcept C2780255968 @default.
- W4367393784 hasConcept C2780699399 @default.
- W4367393784 hasConcept C523546767 @default.
- W4367393784 hasConcept C54355233 @default.
- W4367393784 hasConcept C71924100 @default.
- W4367393784 hasConcept C86803240 @default.
- W4367393784 hasConcept C90924648 @default.
- W4367393784 hasConcept C95150158 @default.
- W4367393784 hasConceptScore W4367393784C126322002 @default.
- W4367393784 hasConceptScore W4367393784C142724271 @default.
- W4367393784 hasConceptScore W4367393784C16005928 @default.
- W4367393784 hasConceptScore W4367393784C197934379 @default.
- W4367393784 hasConceptScore W4367393784C204787440 @default.
- W4367393784 hasConceptScore W4367393784C27081682 @default.
- W4367393784 hasConceptScore W4367393784C2778329239 @default.
- W4367393784 hasConceptScore W4367393784C2778370115 @default.
- W4367393784 hasConceptScore W4367393784C2780255968 @default.
- W4367393784 hasConceptScore W4367393784C2780699399 @default.
- W4367393784 hasConceptScore W4367393784C523546767 @default.
- W4367393784 hasConceptScore W4367393784C54355233 @default.
- W4367393784 hasConceptScore W4367393784C71924100 @default.
- W4367393784 hasConceptScore W4367393784C86803240 @default.
- W4367393784 hasConceptScore W4367393784C90924648 @default.
- W4367393784 hasConceptScore W4367393784C95150158 @default.
- W4367393784 hasLocation W43673937841 @default.
- W4367393784 hasOpenAccess W4367393784 @default.
- W4367393784 hasPrimaryLocation W43673937841 @default.
- W4367393784 hasRelatedWork W2591391070 @default.
- W4367393784 hasRelatedWork W2605620008 @default.
- W4367393784 hasRelatedWork W2810554503 @default.
- W4367393784 hasRelatedWork W2884557367 @default.
- W4367393784 hasRelatedWork W2905568634 @default.
- W4367393784 hasRelatedWork W3110528957 @default.
- W4367393784 hasRelatedWork W4321435758 @default.
- W4367393784 hasRelatedWork W4367393784 @default.
- W4367393784 hasRelatedWork W4376871458 @default.
- W4367393784 hasRelatedWork W1470756582 @default.
- W4367393784 isParatext "false" @default.
- W4367393784 isRetracted "false" @default.
- W4367393784 workType "article" @default.