Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367393793> ?p ?o ?g. }
- W4367393793 abstract "The epigenetic modification 5-methylcytosine plays a vital role in development, cell specific gene expression and disease states. The selective chemical modification of the 5-methylcytosine methyl group is challenging. Currently, no such chemistry exists. Direct functionalisation of 5-methylcytosine would improve the detection and study of this epigenetic feature. We report a xanthone-photosensitised process that introduces a 4-pyridine modification at a C(sp3)-H bond in the methyl group of 5-methylcytosine. We propose a reaction mechanism for this type of reaction based on density functional calculations and apply transition state analysis to rationalise differences in observed reaction efficiencies between cyanopyridine derivatives. The reaction is initiated by single electron oxidation of 5-methylcytosine followed by deprotonation to generate the methyl group radical. Cross coupling of the methyl radical with 4-cyanopyridine installs a 4-pyridine label at 5-methylcytosine. We demonstrate use of the pyridination reaction to enrich 5-methylcytosine-containing RNA." @default.
- W4367393793 created "2023-04-30" @default.
- W4367393793 creator A5009209408 @default.
- W4367393793 creator A5040551102 @default.
- W4367393793 creator A5068448932 @default.
- W4367393793 creator A5086984299 @default.
- W4367393793 date "2023-05-15" @default.
- W4367393793 modified "2023-09-26" @default.
- W4367393793 title "Selective Functionalisation of 5‐Methylcytosine by Organic Photoredox Catalysis" @default.
- W4367393793 cites W1271208340 @default.
- W4367393793 cites W1969408680 @default.
- W4367393793 cites W1979273476 @default.
- W4367393793 cites W1980421351 @default.
- W4367393793 cites W1987658864 @default.
- W4367393793 cites W1991463958 @default.
- W4367393793 cites W2023271753 @default.
- W4367393793 cites W2024131391 @default.
- W4367393793 cites W2025429390 @default.
- W4367393793 cites W2031317139 @default.
- W4367393793 cites W2035425817 @default.
- W4367393793 cites W2037631993 @default.
- W4367393793 cites W2038820367 @default.
- W4367393793 cites W2058767191 @default.
- W4367393793 cites W2060902122 @default.
- W4367393793 cites W2071491849 @default.
- W4367393793 cites W2086957099 @default.
- W4367393793 cites W2088452832 @default.
- W4367393793 cites W2096747776 @default.
- W4367393793 cites W2105938928 @default.
- W4367393793 cites W2112850441 @default.
- W4367393793 cites W2131640038 @default.
- W4367393793 cites W2143981217 @default.
- W4367393793 cites W2160790360 @default.
- W4367393793 cites W2172087672 @default.
- W4367393793 cites W2295995177 @default.
- W4367393793 cites W2418726947 @default.
- W4367393793 cites W2579273737 @default.
- W4367393793 cites W2757739379 @default.
- W4367393793 cites W2907236505 @default.
- W4367393793 cites W2911756720 @default.
- W4367393793 cites W2916127307 @default.
- W4367393793 cites W2922152634 @default.
- W4367393793 cites W2942949465 @default.
- W4367393793 cites W3027531807 @default.
- W4367393793 cites W3112885987 @default.
- W4367393793 cites W3118684081 @default.
- W4367393793 cites W3176791230 @default.
- W4367393793 cites W3196608528 @default.
- W4367393793 cites W4307495488 @default.
- W4367393793 cites W4308697814 @default.
- W4367393793 doi "https://doi.org/10.1002/ange.202304756" @default.
- W4367393793 hasPublicationYear "2023" @default.
- W4367393793 type Work @default.
- W4367393793 citedByCount "0" @default.
- W4367393793 crossrefType "journal-article" @default.
- W4367393793 hasAuthorship W4367393793A5009209408 @default.
- W4367393793 hasAuthorship W4367393793A5040551102 @default.
- W4367393793 hasAuthorship W4367393793A5068448932 @default.
- W4367393793 hasAuthorship W4367393793A5086984299 @default.
- W4367393793 hasBestOaLocation W43673937931 @default.
- W4367393793 hasConcept C104317684 @default.
- W4367393793 hasConcept C118629725 @default.
- W4367393793 hasConcept C145148216 @default.
- W4367393793 hasConcept C150194340 @default.
- W4367393793 hasConcept C178790620 @default.
- W4367393793 hasConcept C185592680 @default.
- W4367393793 hasConcept C190727270 @default.
- W4367393793 hasConcept C21951064 @default.
- W4367393793 hasConcept C2775926025 @default.
- W4367393793 hasConcept C2777332933 @default.
- W4367393793 hasConcept C2778565081 @default.
- W4367393793 hasConcept C2781311116 @default.
- W4367393793 hasConcept C41091548 @default.
- W4367393793 hasConcept C521977710 @default.
- W4367393793 hasConcept C55493867 @default.
- W4367393793 hasConceptScore W4367393793C104317684 @default.
- W4367393793 hasConceptScore W4367393793C118629725 @default.
- W4367393793 hasConceptScore W4367393793C145148216 @default.
- W4367393793 hasConceptScore W4367393793C150194340 @default.
- W4367393793 hasConceptScore W4367393793C178790620 @default.
- W4367393793 hasConceptScore W4367393793C185592680 @default.
- W4367393793 hasConceptScore W4367393793C190727270 @default.
- W4367393793 hasConceptScore W4367393793C21951064 @default.
- W4367393793 hasConceptScore W4367393793C2775926025 @default.
- W4367393793 hasConceptScore W4367393793C2777332933 @default.
- W4367393793 hasConceptScore W4367393793C2778565081 @default.
- W4367393793 hasConceptScore W4367393793C2781311116 @default.
- W4367393793 hasConceptScore W4367393793C41091548 @default.
- W4367393793 hasConceptScore W4367393793C521977710 @default.
- W4367393793 hasConceptScore W4367393793C55493867 @default.
- W4367393793 hasFunder F4320311904 @default.
- W4367393793 hasFunder F4320334670 @default.
- W4367393793 hasFunder F4320337195 @default.
- W4367393793 hasIssue "26" @default.
- W4367393793 hasLocation W43673937931 @default.
- W4367393793 hasOpenAccess W4367393793 @default.
- W4367393793 hasPrimaryLocation W43673937931 @default.
- W4367393793 hasRelatedWork W1995960814 @default.
- W4367393793 hasRelatedWork W2042031417 @default.
- W4367393793 hasRelatedWork W2079853062 @default.