FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367394148> ?p ?o ?g. }

• W4367394148 abstract "Abstract Resuscitation induced ischemia/reperfusion predisposes trauma patients to systemic inflammation and organ dysfunction. We investigated the effect of remote ischemic conditioning (RIC), a treatment shown to prevent ischemia/reperfusion injury in experimental models of hemorrhagic shock/resuscitation, on the systemic immune-inflammatory profile in trauma patients in a randomized trial. We conducted a prospective, single-centre, double-blind, randomized, controlled trial involving trauma patients sustaining blunt or penetrating trauma in hemorrhagic shock admitted to a Level 1 trauma centre. Patients were randomized to receive RIC (four cycles of 5-min pressure cuff inflation at 250 mmHg and deflation on the thigh) or a Sham intervention. The primary outcomes were neutrophil oxidative burst activity, cellular adhesion molecule expression, and plasma levels of myeloperoxidase, cytokines and chemokines in peripheral blood samples, drawn at admission (pre-intervention), 1 h, 3 h, and 24 h post-admission. Secondary outcomes included ventilator, ICU and hospital free days, incidence of nosocomial infections, 24 h and 28 day mortality. 50 eligible patients were randomized; of which 21 in the Sham group and 18 in the RIC group were included in the full analysis. No treatment effect was observed between Sham and RIC groups for neutrophil oxidative burst activity, adhesion molecule expression, and plasma levels of myeloperoxidase and cytokines. RIC prevented significant increases in Th2 chemokines TARC/CCL17 (P < 0.01) and MDC/CCL22 (P < 0.05) at 24 h post-intervention in comparison to the Sham group. Secondary clinical outcomes were not different between groups. No adverse events in relation to the RIC intervention were observed. Administration of RIC was safe and did not adversely affect clinical outcomes. While trauma itself modified several immunoregulatory markers, RIC failed to alter expression of the majority of markers. However, RIC may influence Th2 chemokine expression in the post resuscitation period. Further investigation into the immunomodulatory effects of RIC in traumatic injuries and their impact on clinical outcomes is warranted. ClinicalTrials.gov number: NCT02071290." @default.
• W4367394148 created "2023-04-30" @default.
• W4367394148 creator A5000855379 @default.
• W4367394148 creator A5004819829 @default.
• W4367394148 creator A5041592272 @default.
• W4367394148 creator A5046819268 @default.
• W4367394148 creator A5068089001 @default.
• W4367394148 creator A5082613337 @default.
• W4367394148 creator A5089941344 @default.
• W4367394148 date "2023-04-29" @default.
• W4367394148 modified "2023-10-01" @default.
• W4367394148 title "Effect of remote ischemic conditioning on the immune-inflammatory profile in patients with traumatic hemorrhagic shock in a randomized controlled trial" @default.
• W4367394148 cites W16606664 @default.
• W4367394148 cites W1929903403 @default.
• W4367394148 cites W1966947716 @default.
• W4367394148 cites W1988592848 @default.
• W4367394148 cites W2001851523 @default.
• W4367394148 cites W2012104272 @default.
• W4367394148 cites W2012517632 @default.
• W4367394148 cites W2032941828 @default.
• W4367394148 cites W2044847181 @default.
• W4367394148 cites W2047841734 @default.
• W4367394148 cites W2065484205 @default.
• W4367394148 cites W2094951388 @default.
• W4367394148 cites W2098565046 @default.
• W4367394148 cites W2100737789 @default.
• W4367394148 cites W2103606060 @default.
• W4367394148 cites W2115711765 @default.
• W4367394148 cites W2119081331 @default.
• W4367394148 cites W2119235151 @default.
• W4367394148 cites W2129741568 @default.
• W4367394148 cites W2130158896 @default.
• W4367394148 cites W2164007663 @default.
• W4367394148 cites W2281735941 @default.
• W4367394148 cites W2332389703 @default.
• W4367394148 cites W2334672311 @default.
• W4367394148 cites W2560741051 @default.
• W4367394148 cites W2586773298 @default.
• W4367394148 cites W2597147477 @default.
• W4367394148 cites W2732727211 @default.
• W4367394148 cites W2753051611 @default.
• W4367394148 cites W2759367513 @default.
• W4367394148 cites W2790972620 @default.
• W4367394148 cites W2892809591 @default.
• W4367394148 cites W2903055263 @default.
• W4367394148 cites W2905762126 @default.
• W4367394148 cites W2972010323 @default.
• W4367394148 cites W2995377865 @default.
• W4367394148 cites W3004371339 @default.
• W4367394148 cites W3038341522 @default.
• W4367394148 cites W3093421602 @default.
• W4367394148 cites W3114074405 @default.
• W4367394148 cites W3176566115 @default.
• W4367394148 cites W3182600815 @default.
• W4367394148 cites W3197925515 @default.
• W4367394148 cites W3205039934 @default.
• W4367394148 cites W3205768401 @default.
• W4367394148 cites W4214951806 @default.
• W4367394148 cites W4220676510 @default.
• W4367394148 cites W4281250718 @default.
• W4367394148 cites W4304187626 @default.
• W4367394148 cites W831416 @default.
• W4367394148 doi "https://doi.org/10.1038/s41598-023-33681-3" @default.
• W4367394148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37120600" @default.
• W4367394148 hasPublicationYear "2023" @default.
• W4367394148 type Work @default.
• W4367394148 citedByCount "0" @default.
• W4367394148 crossrefType "journal-article" @default.
• W4367394148 hasAuthorship W4367394148A5000855379 @default.
• W4367394148 hasAuthorship W4367394148A5004819829 @default.
• W4367394148 hasAuthorship W4367394148A5041592272 @default.
• W4367394148 hasAuthorship W4367394148A5046819268 @default.
• W4367394148 hasAuthorship W4367394148A5068089001 @default.
• W4367394148 hasAuthorship W4367394148A5082613337 @default.
• W4367394148 hasAuthorship W4367394148A5089941344 @default.
• W4367394148 hasBestOaLocation W43673941481 @default.
• W4367394148 hasConcept C126322002 @default.
• W4367394148 hasConcept C13373296 @default.
• W4367394148 hasConcept C168563851 @default.
• W4367394148 hasConcept C203014093 @default.
• W4367394148 hasConcept C2776914184 @default.
• W4367394148 hasConcept C2778165595 @default.
• W4367394148 hasConcept C2778384902 @default.
• W4367394148 hasConcept C2778426790 @default.
• W4367394148 hasConcept C2780835948 @default.
• W4367394148 hasConcept C2781300812 @default.
• W4367394148 hasConcept C42219234 @default.
• W4367394148 hasConcept C71924100 @default.
• W4367394148 hasConcept C90924648 @default.
• W4367394148 hasConceptScore W4367394148C126322002 @default.
• W4367394148 hasConceptScore W4367394148C13373296 @default.
• W4367394148 hasConceptScore W4367394148C168563851 @default.
• W4367394148 hasConceptScore W4367394148C203014093 @default.
• W4367394148 hasConceptScore W4367394148C2776914184 @default.
• W4367394148 hasConceptScore W4367394148C2778165595 @default.
• W4367394148 hasConceptScore W4367394148C2778384902 @default.
• W4367394148 hasConceptScore W4367394148C2778426790 @default.
• W4367394148 hasConceptScore W4367394148C2780835948 @default.
• W4367394148 hasConceptScore W4367394148C2781300812 @default.
• W4367394148 hasConceptScore W4367394148C42219234 @default.

• next