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• W4367394469 abstract "What is the central question of this study? How well have studies using ex vivo muscle- nerve preparations represented in vivo features of sensory encoding by low threshold mechanoreceptors in muscle? What is the main finding and its importance? We find experimental adjustments to the ex vivo approach that improve representation of mechanosensory encoding observed in vivo. These adjustments will enhance accuracy in the search for molecular identity and encoding mechanisms of heterogeneous muscle mechanosensory neurons.Our objective was to evaluate an ex vivo muscle-nerve preparation used to study mechanosensory signalling by low threshold mechanosensory receptors (LTMRs). Specifically, we aimed to assess how well the ex vivo preparation represents in vivo firing behaviours of the three major LTMR subtypes of muscle primary sensory afferents, namely type Ia and II muscle spindle (MS) afferents and type Ib tendon organ afferents. Using published procedures for ex vivo study of LTMRs in mouse hindlimb muscles, we replicated earlier reports on afferent firing in response to conventional stretch paradigms applied to non-contracting, that is passive, muscle. Relative to in vivo studies, stretch-evoked firing for confirmed MS afferents in the ex vivo preparation was markedly reduced in firing rate and deficient in encoding dynamic features of muscle stretch. These deficiencies precluded conventional means of discriminating type Ia and II afferents. Muscle afferents, including confirmed Ib afferents were often indistinguishable based on their similar firing responses to the same physiologically relevant stretch paradigms. These observations raise uncertainty about conclusions drawn from earlier ex vivo studies that either attribute findings to specific afferent types or suggest an absence of treatment effects on dynamic firing. However, we found that replacing the recording solution with bicarbonate buffer resulted in afferent firing rates and profiles more like those seen in vivo. Improving representation of the distinctive sensory encoding properties in ex vivo muscle-nerve preparations will promote accuracy in assigning molecular markers and mechanisms to heterogeneous types of muscle mechanosensory neurons." @default.
• W4367394469 created "2023-04-30" @default.
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• W4367394469 date "2023-04-29" @default.
• W4367394469 modified "2023-10-10" @default.
• W4367394469 title "Mechanosensory encoding in ex vivo muscle–nerve preparations" @default.
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• W4367394469 doi "https://doi.org/10.1113/ep090763" @default.
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• W4367394469 hasPublicationYear "2023" @default.
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