Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367394788> ?p ?o ?g. }
- W4367394788 endingPage "798" @default.
- W4367394788 startingPage "785" @default.
- W4367394788 abstract "Introduction The skin is an attractive route for drug delivery. However, the stratum corneum is a critical limiting barrier for drug permeation. Nanoentrapment is a way to enhance cutaneous drug delivery, by diverse mechanisms, with a notable trend of nanoparticles accumulating into the hair follicles when topically applied. Iontophoresis is yet another way of increasing drug transport by applying a mild electrical field that preferentially passes through the hair follicles, for being the pathway of lower resistance. So, iontophoresis application to nanocarriers could further increase actives accumulation into the hair follicles, impacting cutaneous drug delivery.Areas covered In this review, the authors aimed to discuss the main factors impacting iontophoretic skin transport when combining nanocarriers with iontophoresis. We further provide an overview of the conditions in which this combination has been studied, the characteristics of nanosystems employed, and hypothesize why the association has succeeded or failed to enhance drug permeation.Expert opinion Nanocarriers and iontophoresis association can be promising to enhance cutaneous drug delivery. For better results, the electroosmotic contribution to the iontophoretic transport, mainly of negatively charged nanocarriers, charge density, formulation pH, and skin models should be considered. Moreover, the transfollicular pathway should be considered, especially when designing the nanocarriers." @default.
- W4367394788 created "2023-04-30" @default.
- W4367394788 creator A5043288439 @default.
- W4367394788 creator A5046369704 @default.
- W4367394788 creator A5060838517 @default.
- W4367394788 creator A5076102682 @default.
- W4367394788 date "2023-05-03" @default.
- W4367394788 modified "2023-10-18" @default.
- W4367394788 title "Iontophoresis for the cutaneous delivery of nanoentraped drugs" @default.
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