FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367395038> ?p ?o ?g. }

• W4367395038 endingPage "522" @default.
• W4367395038 startingPage "505" @default.
• W4367395038 abstract "Intraplaque (IP) angiogenesis is a key feature of advanced atherosclerotic plaques. Because IP vessels are fragile and leaky, erythrocytes are released and phagocytosed by macrophages (erythrophagocytosis), which leads to high intracellular iron content, lipid peroxidation and cell death. In vitro experiments showed that erythrophagocytosis by macrophages induced non-canonical ferroptosis, an emerging type of regulated necrosis that may contribute to plaque destabilization. Erythrophagocytosis-induced ferroptosis was accompanied by increased expression of heme-oxygenase 1 and ferritin, and could be blocked by co-treatment with third generation ferroptosis inhibitor UAMC-3203. Both heme-oxygenase 1 and ferritin were also expressed in erythrocyte-rich regions of carotid plaques from ApoE-/- Fbn1C1039G+/- mice, a model of advanced atherosclerosis with IP angiogenesis. The effect of UAMC-3203 (12.35 mg/kg/day) on atherosclerosis was evaluated in ApoE-/- Fbn1C1039G+/- mice fed a western-type diet (WD) for 12 weeks (n = 13 mice/group) or 20 weeks (n = 16-21 mice/group) to distinguish between plaques without and with established IP angiogenesis, respectively. A significant decrease in carotid plaque thickness was observed after 20 weeks WD (87 ± 19 μm vs. 166 ± 20 μm, p = 0.006), particularly in plaques with confirmed IP angiogenesis or hemorrhage (108 ± 35 μm vs. 322 ± 40 μm, p = 0.004). This effect was accompanied by decreased IP heme-oxygenase 1 and ferritin expression. UAMC-3203 did not affect carotid plaques after 12 weeks WD or plaques in the aorta, which typically do not develop IP angiogenesis. Altogether, erythrophagocytosis-induced ferroptosis during IP angiogenesis leads to larger atherosclerotic plaques, an effect that can be prevented by ferroptosis inhibitor UAMC-3203." @default.
• W4367395038 created "2023-04-30" @default.
• W4367395038 creator A5008950728 @default.
• W4367395038 creator A5013840465 @default.
• W4367395038 creator A5017391096 @default.
• W4367395038 creator A5045812576 @default.
• W4367395038 creator A5059862918 @default.
• W4367395038 creator A5063161881 @default.
• W4367395038 creator A5072677920 @default.
• W4367395038 creator A5073647450 @default.
• W4367395038 creator A5076009877 @default.
• W4367395038 creator A5080336803 @default.
• W4367395038 creator A5080874961 @default.
• W4367395038 creator A5087011923 @default.
• W4367395038 date "2023-04-29" @default.
• W4367395038 modified "2023-10-15" @default.
• W4367395038 title "Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques" @default.
• W4367395038 cites W1997183854 @default.
• W4367395038 cites W2001019228 @default.
• W4367395038 cites W2002490399 @default.
• W4367395038 cites W2054258901 @default.
• W4367395038 cites W2057396923 @default.
• W4367395038 cites W2063258382 @default.
• W4367395038 cites W2079909947 @default.
• W4367395038 cites W2085090882 @default.
• W4367395038 cites W2093212994 @default.
• W4367395038 cites W2095819288 @default.
• W4367395038 cites W2117693547 @default.
• W4367395038 cites W2128048508 @default.
• W4367395038 cites W2128843953 @default.
• W4367395038 cites W2138138539 @default.
• W4367395038 cites W2159767534 @default.
• W4367395038 cites W2168508349 @default.
• W4367395038 cites W2168517860 @default.
• W4367395038 cites W2213626759 @default.
• W4367395038 cites W2592029987 @default.
• W4367395038 cites W2615751376 @default.
• W4367395038 cites W2766161804 @default.
• W4367395038 cites W2778627538 @default.
• W4367395038 cites W2801527259 @default.
• W4367395038 cites W2809820903 @default.
• W4367395038 cites W2891613655 @default.
• W4367395038 cites W2898335558 @default.
• W4367395038 cites W2951566019 @default.
• W4367395038 cites W2999151985 @default.
• W4367395038 cites W3047356675 @default.
• W4367395038 cites W3137964820 @default.
• W4367395038 cites W3198503384 @default.
• W4367395038 cites W4213442676 @default.
• W4367395038 cites W4223927553 @default.
• W4367395038 cites W4226210301 @default.
• W4367395038 cites W4280492929 @default.
• W4367395038 cites W4296618007 @default.
• W4367395038 doi "https://doi.org/10.1007/s10456-023-09877-6" @default.
• W4367395038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37120604" @default.
• W4367395038 hasPublicationYear "2023" @default.
• W4367395038 type Work @default.
• W4367395038 citedByCount "1" @default.
• W4367395038 countsByYear W43673950382023 @default.
• W4367395038 crossrefType "journal-article" @default.
• W4367395038 hasAuthorship W4367395038A5008950728 @default.
• W4367395038 hasAuthorship W4367395038A5013840465 @default.
• W4367395038 hasAuthorship W4367395038A5017391096 @default.
• W4367395038 hasAuthorship W4367395038A5045812576 @default.
• W4367395038 hasAuthorship W4367395038A5059862918 @default.
• W4367395038 hasAuthorship W4367395038A5063161881 @default.
• W4367395038 hasAuthorship W4367395038A5072677920 @default.
• W4367395038 hasAuthorship W4367395038A5073647450 @default.
• W4367395038 hasAuthorship W4367395038A5076009877 @default.
• W4367395038 hasAuthorship W4367395038A5080336803 @default.
• W4367395038 hasAuthorship W4367395038A5080874961 @default.
• W4367395038 hasAuthorship W4367395038A5087011923 @default.
• W4367395038 hasBestOaLocation W43673950381 @default.
• W4367395038 hasConcept C126322002 @default.
• W4367395038 hasConcept C12722491 @default.
• W4367395038 hasConcept C142724271 @default.
• W4367395038 hasConcept C181199279 @default.
• W4367395038 hasConcept C185592680 @default.
• W4367395038 hasConcept C202751555 @default.
• W4367395038 hasConcept C203014093 @default.
• W4367395038 hasConcept C2776217839 @default.
• W4367395038 hasConcept C2778271429 @default.
• W4367395038 hasConcept C2778319317 @default.
• W4367395038 hasConcept C2779219270 @default.
• W4367395038 hasConcept C2779244956 @default.
• W4367395038 hasConcept C2780394083 @default.
• W4367395038 hasConcept C502942594 @default.
• W4367395038 hasConcept C55493867 @default.
• W4367395038 hasConcept C71924100 @default.
• W4367395038 hasConcept C86803240 @default.
• W4367395038 hasConceptScore W4367395038C126322002 @default.
• W4367395038 hasConceptScore W4367395038C12722491 @default.
• W4367395038 hasConceptScore W4367395038C142724271 @default.
• W4367395038 hasConceptScore W4367395038C181199279 @default.
• W4367395038 hasConceptScore W4367395038C185592680 @default.
• W4367395038 hasConceptScore W4367395038C202751555 @default.
• W4367395038 hasConceptScore W4367395038C203014093 @default.
• W4367395038 hasConceptScore W4367395038C2776217839 @default.

• next