FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367397344> ?p ?o ?g. }

• W4367397344 endingPage "122990" @default.
• W4367397344 startingPage "122990" @default.
• W4367397344 abstract "Intranasal vaccination by directly applying a vaccine dry powder is appealing. However, a method that can be used to transform a vaccine from a liquid to a dry powder and a device that can be used to administer the powder to the desired region(s) of the nasal cavity are critical for successful intranasal vaccination. In the present study, using a model vaccine that contains liposomal monophosphoryl lipid A and QS-21 adjuvant (AdjLMQ) and ovalbumin (OVA) as a model antigen, it was shown that thin-film freeze-drying can be applied to convert the liquid vaccine containing sucrose at a sucrose to lipid ratio of 15:1 (w/w) into dry powders, in the presence or absence of carboxymethyl cellulose sodium salt (CMC) as a mucoadhesive agent. Ultimately, the thin-film freeze-dried AdjLMQ/OVA vaccine powder containing 1.9% (w/w) of CMC (i.e., TFF AdjLMQ/OVA/CMC1.9% powder) was selected for additional evaluation because the TFF AdjLMQ/OVA/CMC1.9% powder was mucoadhesive and maintained the integrity of the antigen and the physical properties of the vaccine. Compared to the TFF AdjLMQ/OVA powder that did not contain CMC, the TFF AdjLMQ/OVA/CMC1.9% powder had a lower moisture content and a higher glass transition temperature. In addition, the TFF AdjLMQ/OVA/CMC1.9% thin films were relatively thicker than the TFF AdjLMQ/OVA thin films without CMC. When sprayed with Aptar Pharma’s Unidose Powder Nasal Spray System (UDSP), the TFF AdjLMQ/OVA powder and the TFF AdjLMQ/OVA/CMC1.9% powder generated similar particle size distribution curves, spray patterns, and plume geometries. Importantly, after the TFF AdjLMQ/OVA/CMC1.9% powder was sprayed with the UDSP nasal device, the integrity of the OVA antigen and the AdjLMQ liposomes did not change. Finally, a Taguchi L4 orthogonal array was applied to identify the optimal parameters for using the UDSP device to deliver the TFF AdjLMQ/OVA/CMC1.9% powder to the middle and lower turbinate and the nasopharynx regions in both adult and child nasal replica casts. Results from this study showed that it is feasible to apply the thin-film freeze-drying technology to transform a nasal vaccine candidate from liquid to a dry powder and then use the UDSP nasal device to deliver the vaccine powder to the desired regions in the nasal cavity for intranasal vaccination." @default.
• W4367397344 created "2023-04-30" @default.
• W4367397344 creator A5008382683 @default.
• W4367397344 creator A5019402850 @default.
• W4367397344 creator A5019690190 @default.
• W4367397344 creator A5023576409 @default.
• W4367397344 creator A5054449543 @default.
• W4367397344 creator A5055542138 @default.
• W4367397344 creator A5056383338 @default.
• W4367397344 creator A5074905980 @default.
• W4367397344 creator A5087576156 @default.
• W4367397344 creator A5088757599 @default.
• W4367397344 date "2023-06-01" @default.
• W4367397344 modified "2023-10-16" @default.
• W4367397344 title "Feasibility of intranasal delivery of thin-film freeze-dried, mucoadhesive vaccine powders" @default.
• W4367397344 cites W1494681965 @default.
• W4367397344 cites W1964394179 @default.
• W4367397344 cites W1968440984 @default.
• W4367397344 cites W1970550264 @default.
• W4367397344 cites W1977037244 @default.
• W4367397344 cites W1984612027 @default.
• W4367397344 cites W1998166518 @default.
• W4367397344 cites W1998624966 @default.
• W4367397344 cites W2001101891 @default.
• W4367397344 cites W2025767983 @default.
• W4367397344 cites W2031165508 @default.
• W4367397344 cites W2037795881 @default.
• W4367397344 cites W2059175012 @default.
• W4367397344 cites W2111726077 @default.
• W4367397344 cites W2116187491 @default.
• W4367397344 cites W2123013063 @default.
• W4367397344 cites W2131761352 @default.
• W4367397344 cites W2157628817 @default.
• W4367397344 cites W2162143419 @default.
• W4367397344 cites W2277532409 @default.
• W4367397344 cites W2331731708 @default.
• W4367397344 cites W2551653132 @default.
• W4367397344 cites W2614353436 @default.
• W4367397344 cites W2792113920 @default.
• W4367397344 cites W2884883765 @default.
• W4367397344 cites W2897790922 @default.
• W4367397344 cites W3016121249 @default.
• W4367397344 cites W3017000841 @default.
• W4367397344 cites W3087408519 @default.
• W4367397344 cites W3124037640 @default.
• W4367397344 cites W3139469655 @default.
• W4367397344 cites W3186891680 @default.
• W4367397344 cites W3201158859 @default.
• W4367397344 cites W3205800931 @default.
• W4367397344 cites W3211526003 @default.
• W4367397344 cites W4211240312 @default.
• W4367397344 cites W4224094753 @default.
• W4367397344 cites W4280554624 @default.
• W4367397344 cites W4285038407 @default.
• W4367397344 cites W4285097590 @default.
• W4367397344 cites W4303446594 @default.
• W4367397344 cites W4304112065 @default.
• W4367397344 cites W4304190013 @default.
• W4367397344 doi "https://doi.org/10.1016/j.ijpharm.2023.122990" @default.
• W4367397344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37127138" @default.
• W4367397344 hasPublicationYear "2023" @default.
• W4367397344 type Work @default.
• W4367397344 citedByCount "0" @default.
• W4367397344 crossrefType "journal-article" @default.
• W4367397344 hasAuthorship W4367397344A5008382683 @default.
• W4367397344 hasAuthorship W4367397344A5019402850 @default.
• W4367397344 hasAuthorship W4367397344A5019690190 @default.
• W4367397344 hasAuthorship W4367397344A5023576409 @default.
• W4367397344 hasAuthorship W4367397344A5054449543 @default.
• W4367397344 hasAuthorship W4367397344A5055542138 @default.
• W4367397344 hasAuthorship W4367397344A5056383338 @default.
• W4367397344 hasAuthorship W4367397344A5074905980 @default.
• W4367397344 hasAuthorship W4367397344A5087576156 @default.
• W4367397344 hasAuthorship W4367397344A5088757599 @default.
• W4367397344 hasConcept C13245373 @default.
• W4367397344 hasConcept C147483822 @default.
• W4367397344 hasConcept C171250308 @default.
• W4367397344 hasConcept C185592680 @default.
• W4367397344 hasConcept C191897082 @default.
• W4367397344 hasConcept C192562407 @default.
• W4367397344 hasConcept C203014093 @default.
• W4367397344 hasConcept C2776081644 @default.
• W4367397344 hasConcept C2776946954 @default.
• W4367397344 hasConcept C2777239854 @default.
• W4367397344 hasConcept C2777863537 @default.
• W4367397344 hasConcept C2779587474 @default.
• W4367397344 hasConcept C2779820397 @default.
• W4367397344 hasConcept C2780020223 @default.
• W4367397344 hasConcept C43617362 @default.
• W4367397344 hasConcept C537181965 @default.
• W4367397344 hasConcept C71924100 @default.
• W4367397344 hasConcept C84199377 @default.
• W4367397344 hasConcept C85663871 @default.
• W4367397344 hasConcept C98274493 @default.
• W4367397344 hasConceptScore W4367397344C13245373 @default.
• W4367397344 hasConceptScore W4367397344C147483822 @default.
• W4367397344 hasConceptScore W4367397344C171250308 @default.
• W4367397344 hasConceptScore W4367397344C185592680 @default.

• next