Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367397424> ?p ?o ?g. }
- W4367397424 endingPage "116518" @default.
- W4367397424 startingPage "116518" @default.
- W4367397424 abstract "Functional dyspepsia (FD), a chronic upper gastrointestinal syndrome, seriously affects the quality of life of patients and poses a significant economic burden. Since the pathological mechanisms of FD have not been fully elucidated, conventional therapies such as prokinetics, proton pump inhibitors, and antidepressants have some limitations. Siho-sogan-san (SHS) is commonly used as a therapeutic alternative in traditional medicine; however, scientific and clinical evidence supporting its application in FD remains insufficient. This review aimed to assess the safety and effectiveness of SHS and in combined with Western medicine (WM) for the treatment of FD. Eleven databases, including EMBASE, Medline, and Cochrane Library, were searched for randomized controlled trials (RCTs) on FD published before December 31, 2022. After two independent reveiwers sceened and selected studies according to the inclusion and exclusion criteria, clinical data was pooled and synthesized via Review Manager software. The outcome parameters included total clinical effectiveness rate (TCE), time for symptom improvement, levels of motilin and corticotropin-releasing hormone (CRH), and adverse events. Cochrane's risk of bias tool was used for quality assessment. A total of 12 studies that included 867 participants comparing WM with SHS or combination therapy (SHS plus WM) were identified. Through a meta-analysis of five studies including 363 patients, SHS compared with WM showed a positive result in safely increasing TCE [risk ratio = 1.36, 95% confidence interval (CI) 1.22 to 1.51, P < 0.00001]. The time for symptom improvement, including abdominal pain, belching, nausea, vomiting, and abdominal distension, was significantly more shortened in the combination therapy than WM group. Furthermore, combination therapy resulted in greater secretion of motilin than WM alone [mean difference = 67.95, 95% CI 39.52 to 96.39, P < 0.00001]. No remarkable difference was observed in CRH levels between the combination therapy and WM groups. For a subgroup analysis, the administration of SHS based on the type of pattern identification (PI) showed larger effect size than in the group that do not consider PI. These results suggest that SHS and combination therapy can be considered effective and safe options for the treatment of FD. However, owing to the low quality of the included studies, more well-designed investigational studies and RCTs with longer treatment and follow-up period are needed." @default.
- W4367397424 created "2023-04-30" @default.
- W4367397424 creator A5005666838 @default.
- W4367397424 creator A5012464563 @default.
- W4367397424 creator A5026534904 @default.
- W4367397424 creator A5047497320 @default.
- W4367397424 creator A5054967394 @default.
- W4367397424 creator A5081356418 @default.
- W4367397424 date "2023-09-01" @default.
- W4367397424 modified "2023-10-14" @default.
- W4367397424 title "Safety and effectiveness of traditional herbal medicine Siho-sogan-san in functional dyspepsia: A systematic review and meta-analysis" @default.
- W4367397424 cites W1541611016 @default.
- W4367397424 cites W1899152401 @default.
- W4367397424 cites W1963608699 @default.
- W4367397424 cites W1969941668 @default.
- W4367397424 cites W1971586143 @default.
- W4367397424 cites W1988569628 @default.
- W4367397424 cites W2000842029 @default.
- W4367397424 cites W2005510049 @default.
- W4367397424 cites W2051259540 @default.
- W4367397424 cites W2058016798 @default.
- W4367397424 cites W2076192945 @default.
- W4367397424 cites W2080986537 @default.
- W4367397424 cites W2097477058 @default.
- W4367397424 cites W2134739627 @default.
- W4367397424 cites W2345655271 @default.
- W4367397424 cites W2511350252 @default.
- W4367397424 cites W2607040727 @default.
- W4367397424 cites W2609672496 @default.
- W4367397424 cites W2789964320 @default.
- W4367397424 cites W2790401799 @default.
- W4367397424 cites W2796317323 @default.
- W4367397424 cites W2914390590 @default.
- W4367397424 cites W2978210294 @default.
- W4367397424 cites W2981059647 @default.
- W4367397424 cites W3022903699 @default.
- W4367397424 cites W3040888305 @default.
- W4367397424 cites W3045299542 @default.
- W4367397424 cites W3118615836 @default.
- W4367397424 cites W3205955687 @default.
- W4367397424 cites W4200186384 @default.
- W4367397424 cites W4224282967 @default.
- W4367397424 cites W4237426764 @default.
- W4367397424 cites W4293901816 @default.
- W4367397424 doi "https://doi.org/10.1016/j.jep.2023.116518" @default.
- W4367397424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37127143" @default.
- W4367397424 hasPublicationYear "2023" @default.
- W4367397424 type Work @default.
- W4367397424 citedByCount "0" @default.
- W4367397424 crossrefType "journal-article" @default.
- W4367397424 hasAuthorship W4367397424A5005666838 @default.
- W4367397424 hasAuthorship W4367397424A5012464563 @default.
- W4367397424 hasAuthorship W4367397424A5026534904 @default.
- W4367397424 hasAuthorship W4367397424A5047497320 @default.
- W4367397424 hasAuthorship W4367397424A5054967394 @default.
- W4367397424 hasAuthorship W4367397424A5081356418 @default.
- W4367397424 hasBestOaLocation W43673974241 @default.
- W4367397424 hasConcept C126322002 @default.
- W4367397424 hasConcept C168563851 @default.
- W4367397424 hasConcept C17744445 @default.
- W4367397424 hasConcept C197934379 @default.
- W4367397424 hasConcept C199539241 @default.
- W4367397424 hasConcept C2776478404 @default.
- W4367397424 hasConcept C2779473830 @default.
- W4367397424 hasConcept C2780580376 @default.
- W4367397424 hasConcept C2780852908 @default.
- W4367397424 hasConcept C44249647 @default.
- W4367397424 hasConcept C535046627 @default.
- W4367397424 hasConcept C71924100 @default.
- W4367397424 hasConcept C82789193 @default.
- W4367397424 hasConcept C95190672 @default.
- W4367397424 hasConceptScore W4367397424C126322002 @default.
- W4367397424 hasConceptScore W4367397424C168563851 @default.
- W4367397424 hasConceptScore W4367397424C17744445 @default.
- W4367397424 hasConceptScore W4367397424C197934379 @default.
- W4367397424 hasConceptScore W4367397424C199539241 @default.
- W4367397424 hasConceptScore W4367397424C2776478404 @default.
- W4367397424 hasConceptScore W4367397424C2779473830 @default.
- W4367397424 hasConceptScore W4367397424C2780580376 @default.
- W4367397424 hasConceptScore W4367397424C2780852908 @default.
- W4367397424 hasConceptScore W4367397424C44249647 @default.
- W4367397424 hasConceptScore W4367397424C535046627 @default.
- W4367397424 hasConceptScore W4367397424C71924100 @default.
- W4367397424 hasConceptScore W4367397424C82789193 @default.
- W4367397424 hasConceptScore W4367397424C95190672 @default.
- W4367397424 hasFunder F4320322034 @default.
- W4367397424 hasFunder F4320322107 @default.
- W4367397424 hasLocation W43673974241 @default.
- W4367397424 hasLocation W43673974242 @default.
- W4367397424 hasOpenAccess W4367397424 @default.
- W4367397424 hasPrimaryLocation W43673974241 @default.
- W4367397424 hasRelatedWork W1967911880 @default.
- W4367397424 hasRelatedWork W2041128529 @default.
- W4367397424 hasRelatedWork W2217553306 @default.
- W4367397424 hasRelatedWork W2358248846 @default.
- W4367397424 hasRelatedWork W243857094 @default.
- W4367397424 hasRelatedWork W2611871817 @default.
- W4367397424 hasRelatedWork W2998848784 @default.