FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367400136> ?p ?o ?g. }

• W4367400136 endingPage "221" @default.
• W4367400136 startingPage "215" @default.
• W4367400136 abstract "Acute agitation is common amongst individuals with bipolar disorder and schizophrenia and represents a medical emergency. Commonly used medications for agitation, such as benzodiazepines and antipsychotics, are often delivered intramuscularly and may cause adverse effects. Non-invasive, effective, and safe alternative treatment options are needed. The purpose of this review article is to describe the efficacy and safety of sublingual formulation of dexmedetomidine (Igalmi), a selective α2-adrenergic receptor agonist, U.S. Food and Drug Administration approved for the treatment of acute agitation in adults with schizophrenia or bipolar I and II disorder. In two phase 3 trials, two dose strengths of sublingual dexmedetomidine 180 μg and 120 μg were safe and effective in managing acute agitation in patients with bipolar disorder or schizophrenia. Both doses significantly reduced Positive and Negative Syndrome Scale-Exited Component scores two hours after receiving a single dose as compared to placebo, indicating a substantial improvement in agitation. The beneficial effects of sublingual dexmedetomidine were achieved without serious adverse events with the most common side effect being mild somnolence. The clinical trial data suggest that sublingual dexmedetomidine represents a safe and effective treatment option in the armamentarium for acute agitation for people with schizophrenia or bipolar disorder." @default.
• W4367400136 created "2023-04-30" @default.
• W4367400136 creator A5054344919 @default.
• W4367400136 creator A5066927905 @default.
• W4367400136 creator A5075900999 @default.
• W4367400136 creator A5091440166 @default.
• W4367400136 date "2023-05-30" @default.
• W4367400136 modified "2023-10-01" @default.
• W4367400136 title "Sublingual Dexmedetomidine for the Treatment of Agitation in Patients with Schizophrenia and Bipolar Disorder" @default.
• W4367400136 cites W2007470158 @default.
• W4367400136 cites W2021599246 @default.
• W4367400136 cites W2076292813 @default.
• W4367400136 cites W2086011500 @default.
• W4367400136 cites W2103303373 @default.
• W4367400136 cites W2130649501 @default.
• W4367400136 cites W2146910950 @default.
• W4367400136 cites W2160013579 @default.
• W4367400136 cites W2161627732 @default.
• W4367400136 cites W2291138254 @default.
• W4367400136 cites W2295127278 @default.
• W4367400136 cites W2346490116 @default.
• W4367400136 cites W2543172631 @default.
• W4367400136 cites W2985377257 @default.
• W4367400136 cites W3015718133 @default.
• W4367400136 cites W3038457588 @default.
• W4367400136 cites W3203112424 @default.
• W4367400136 cites W3212500723 @default.
• W4367400136 cites W4213231733 @default.
• W4367400136 cites W4213337353 @default.
• W4367400136 cites W4226101071 @default.
• W4367400136 cites W4226495099 @default.
• W4367400136 cites W4229007740 @default.
• W4367400136 cites W4236424725 @default.
• W4367400136 cites W4293105665 @default.
• W4367400136 cites W4295974821 @default.
• W4367400136 cites W4297985067 @default.
• W4367400136 cites W4312114916 @default.
• W4367400136 doi "https://doi.org/10.9758/cpn.2023.21.2.215" @default.
• W4367400136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37119214" @default.
• W4367400136 hasPublicationYear "2023" @default.
• W4367400136 type Work @default.
• W4367400136 citedByCount "1" @default.
• W4367400136 countsByYear W43674001362023 @default.
• W4367400136 crossrefType "journal-article" @default.
• W4367400136 hasAuthorship W4367400136A5054344919 @default.
• W4367400136 hasAuthorship W4367400136A5066927905 @default.
• W4367400136 hasAuthorship W4367400136A5075900999 @default.
• W4367400136 hasAuthorship W4367400136A5091440166 @default.
• W4367400136 hasBestOaLocation W43674001361 @default.
• W4367400136 hasConcept C118552586 @default.
• W4367400136 hasConcept C126322002 @default.
• W4367400136 hasConcept C142724271 @default.
• W4367400136 hasConcept C197934379 @default.
• W4367400136 hasConcept C204787440 @default.
• W4367400136 hasConcept C27081682 @default.
• W4367400136 hasConcept C2776153860 @default.
• W4367400136 hasConcept C2776174506 @default.
• W4367400136 hasConcept C2776412080 @default.
• W4367400136 hasConcept C2776809841 @default.
• W4367400136 hasConcept C2776814716 @default.
• W4367400136 hasConcept C2778541603 @default.
• W4367400136 hasConcept C2778609679 @default.
• W4367400136 hasConcept C2779034229 @default.
• W4367400136 hasConcept C2781302539 @default.
• W4367400136 hasConcept C42219234 @default.
• W4367400136 hasConcept C71924100 @default.
• W4367400136 hasConceptScore W4367400136C118552586 @default.
• W4367400136 hasConceptScore W4367400136C126322002 @default.
• W4367400136 hasConceptScore W4367400136C142724271 @default.
• W4367400136 hasConceptScore W4367400136C197934379 @default.
• W4367400136 hasConceptScore W4367400136C204787440 @default.
• W4367400136 hasConceptScore W4367400136C27081682 @default.
• W4367400136 hasConceptScore W4367400136C2776153860 @default.
• W4367400136 hasConceptScore W4367400136C2776174506 @default.
• W4367400136 hasConceptScore W4367400136C2776412080 @default.
• W4367400136 hasConceptScore W4367400136C2776809841 @default.
• W4367400136 hasConceptScore W4367400136C2776814716 @default.
• W4367400136 hasConceptScore W4367400136C2778541603 @default.
• W4367400136 hasConceptScore W4367400136C2778609679 @default.
• W4367400136 hasConceptScore W4367400136C2779034229 @default.
• W4367400136 hasConceptScore W4367400136C2781302539 @default.
• W4367400136 hasConceptScore W4367400136C42219234 @default.
• W4367400136 hasConceptScore W4367400136C71924100 @default.
• W4367400136 hasIssue "2" @default.
• W4367400136 hasLocation W43674001361 @default.
• W4367400136 hasLocation W43674001362 @default.
• W4367400136 hasLocation W43674001363 @default.
• W4367400136 hasOpenAccess W4367400136 @default.
• W4367400136 hasPrimaryLocation W43674001361 @default.
• W4367400136 hasRelatedWork W2056899425 @default.
• W4367400136 hasRelatedWork W2438944784 @default.
• W4367400136 hasRelatedWork W2732772381 @default.
• W4367400136 hasRelatedWork W3029444201 @default.
• W4367400136 hasRelatedWork W3031282144 @default.
• W4367400136 hasRelatedWork W3032607752 @default.
• W4367400136 hasRelatedWork W3171244150 @default.
• W4367400136 hasRelatedWork W4295643881 @default.
• W4367400136 hasRelatedWork W4367400136 @default.

• next