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• W4367481440 abstract "SUMMARY Rosiglitazone, a potent thiazolidinedione oral antidiabetic agent recently approved in the US, differs structurally from pioglitazone and troglitazone (other approved thiazolidinediones), with greater PPARγ binding affinity and antihyperglycaemic potency in preclinical models. Clinical data on more than 4500 patients with type 2 diabetes show that rosiglitazone is a safe, effective monotherapy or combination therapy, producing significant reductions in haemoglobin A 1c and fasting plasma glucose under different dosing regimens. Unlike troglitazone, which has been associated with idiosyncratic hepatotoxicity and rare cases of liver failure and death, rosiglitazone has shown a low incidence of liver abnormalities in more than 3500 patient‐years of exposure. No significant food or drug interactions have been reported. Particularly effective as first‐line therapy, rosiglitazone is a useful addition to the roster of oral antidiabetic agents. (Int J Clin Pract 2000; 54(5): 333‐337)" @default.
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• W4367481440 date "2000-06-01" @default.
• W4367481440 modified "2023-10-14" @default.
• W4367481440 title "ROSIGLITAZONE" @default.
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• W4367481440 doi "https://doi.org/10.1111/j.1742-1241.2000.tb11914.x" @default.
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