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• W4367551093 endingPage "115983" @default.
• W4367551093 startingPage "115983" @default.
• W4367551093 abstract "The bio-based nanoparticles synthesis and assessment of their potential biomedical applications related research is rapidly emerging. The ability of an aqueous ethanolic bark extract of Mangifera indica to synthesize silver nanoparticles (AgNPs) as well as its antibacterial, anti-inflammatory, and anticancer activities were investigated in this study. Interestingly, the bark extract effectively synthesized the AgNPs, including an absorbance peak at 412 nm and sizes ranging from 56 to 89 nm. The Fourier Transform Infrared spectroscopy (FTIR) analysis confirmed that the presence of most essential functional groups belongs to the most bioactive compounds. Synthesized AgNPs showed fine antibacterial activity against the Urinary Tract Infection (UTI) causing bacterial pathogens such as Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Proteus mirabilis, and Staphylococcus saprophyticus at 50 μg mL−1 concentrations. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of AgNPs against these pathogens were found as 12.5 ± 0.8 & 13 ± 0.6, 13.6 ± 0.5 & 14 ± 0.7, 11.5 ± 0.3 & 11.5 ± 0.4, 13 ± 0.8 & 13 ± 0.7, and 11.8 ± 0.4 & 12 ± 0.8 μg mL−1 respectively. Interestingly, this AgNPs also possesses outstanding anti-inflammatory and anticancer activities as studied against the egg albumin denaturation (85%) inhibition and MCF 7 (Michigan Cancer Foundation-7: breast cancer cells) cell line (cytotoxicity: 80.1%) at 50 μg mL−1 concentration. Similarly at 50 μg mL−1 concentration showed 75% of DPPH radical scavenging potential. These activities were dose dependent, and the findings suggest that the M. indica bark aqueous ethanolic extract synthesized AgNPs can be used as antibacterial, anti-inflammatory, and anticancer agents after in-vivo testing." @default.
• W4367551093 created "2023-05-01" @default.
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• W4367551093 date "2023-08-01" @default.
• W4367551093 modified "2023-09-27" @default.
• W4367551093 title "Nanofabrication synthesis and its role in antibacterial, anti-inflammatory, and anticoagulant activities of AgNPs synthesized by Mangifera indica bark extract" @default.
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• W4367551093 doi "https://doi.org/10.1016/j.envres.2023.115983" @default.
• W4367551093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37137456" @default.
• W4367551093 hasPublicationYear "2023" @default.
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