FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367597570> ?p ?o ?g. }

• W4367597570 abstract "Single-cell genetic and epigenetic analyses parse the brain′s billions of neurons into thousands of ″cell type″ clusters, each residing in different brain structures. Many of these cell types mediate their unique functions by virtue of targeted long-distance axonal projections to allow interactions between specific cell types. Here we have used Epi-Retro-Seq to link single cell epigenomes and associated cell types to their long-distance projections for 33,034 neurons dissected from 32 different source regions projecting to 24 different targets (225 source→target combinations) across the whole mouse brain. We highlight uses of this large data set for interrogating both overarching principles relating projection cell types to their transcriptomic and epigenomic properties and for addressing and developing specific hypotheses about cell types and connections as they relate to genetics. We provide an overall synthesis of the data set with 926 statistical comparisons of the discriminability of neurons projecting to each target for every dissected source region. We integrate this dataset into the larger, annotated BICCN cell type atlas composed of millions of neurons to link projection cell types to consensus clusters. Integration with spatial transcriptomic data further assigns projection-enriched clusters to much smaller source regions than afforded by the original dissections. We exemplify these capabilities by presenting in-depth analyses of neurons with identified projections from the hypothalamus, thalamus, hindbrain, amygdala, and midbrain to provide new insights into the properties of those cell types, including differentially expressed genes, their associated cis-regulatory elements and transcription factor binding motifs, and neurotransmitter usage." @default.
• W4367597570 created "2023-05-02" @default.
• W4367597570 creator A5010189175 @default.
• W4367597570 creator A5012251441 @default.
• W4367597570 creator A5014419238 @default.
• W4367597570 creator A5016056992 @default.
• W4367597570 creator A5017745121 @default.
• W4367597570 creator A5017866442 @default.
• W4367597570 creator A5018356507 @default.
• W4367597570 creator A5020833715 @default.
• W4367597570 creator A5021414431 @default.
• W4367597570 creator A5023770267 @default.
• W4367597570 creator A5024679109 @default.
• W4367597570 creator A5025573617 @default.
• W4367597570 creator A5027211550 @default.
• W4367597570 creator A5032802547 @default.
• W4367597570 creator A5033230360 @default.
• W4367597570 creator A5034133150 @default.
• W4367597570 creator A5034688607 @default.
• W4367597570 creator A5035293995 @default.
• W4367597570 creator A5038178720 @default.
• W4367597570 creator A5038566534 @default.
• W4367597570 creator A5038722866 @default.
• W4367597570 creator A5039626601 @default.
• W4367597570 creator A5042285286 @default.
• W4367597570 creator A5042603268 @default.
• W4367597570 creator A5043641903 @default.
• W4367597570 creator A5043968722 @default.
• W4367597570 creator A5044378136 @default.
• W4367597570 creator A5045133318 @default.
• W4367597570 creator A5050507557 @default.
• W4367597570 creator A5053280859 @default.
• W4367597570 creator A5057189874 @default.
• W4367597570 creator A5060773442 @default.
• W4367597570 creator A5062569735 @default.
• W4367597570 creator A5066263096 @default.
• W4367597570 creator A5066697532 @default.
• W4367597570 creator A5068072367 @default.
• W4367597570 creator A5068606243 @default.
• W4367597570 creator A5068784328 @default.
• W4367597570 creator A5068993612 @default.
• W4367597570 creator A5070268950 @default.
• W4367597570 creator A5070542745 @default.
• W4367597570 creator A5070802625 @default.
• W4367597570 creator A5075989575 @default.
• W4367597570 creator A5083942550 @default.
• W4367597570 creator A5085134845 @default.
• W4367597570 creator A5087781969 @default.
• W4367597570 creator A5091176232 @default.
• W4367597570 creator A5091707169 @default.
• W4367597570 date "2023-05-01" @default.
• W4367597570 modified "2023-10-13" @default.
• W4367597570 title "Brain-wide Correspondence Between Neuronal Epigenomics and Long-Distance Projections" @default.
• W4367597570 doi "https://doi.org/10.1101/2023.05.01.538832" @default.
• W4367597570 hasPublicationYear "2023" @default.
• W4367597570 type Work @default.
• W4367597570 citedByCount "0" @default.
• W4367597570 crossrefType "posted-content" @default.
• W4367597570 hasAuthorship W4367597570A5010189175 @default.
• W4367597570 hasAuthorship W4367597570A5012251441 @default.
• W4367597570 hasAuthorship W4367597570A5014419238 @default.
• W4367597570 hasAuthorship W4367597570A5016056992 @default.
• W4367597570 hasAuthorship W4367597570A5017745121 @default.
• W4367597570 hasAuthorship W4367597570A5017866442 @default.
• W4367597570 hasAuthorship W4367597570A5018356507 @default.
• W4367597570 hasAuthorship W4367597570A5020833715 @default.
• W4367597570 hasAuthorship W4367597570A5021414431 @default.
• W4367597570 hasAuthorship W4367597570A5023770267 @default.
• W4367597570 hasAuthorship W4367597570A5024679109 @default.
• W4367597570 hasAuthorship W4367597570A5025573617 @default.
• W4367597570 hasAuthorship W4367597570A5027211550 @default.
• W4367597570 hasAuthorship W4367597570A5032802547 @default.
• W4367597570 hasAuthorship W4367597570A5033230360 @default.
• W4367597570 hasAuthorship W4367597570A5034133150 @default.
• W4367597570 hasAuthorship W4367597570A5034688607 @default.
• W4367597570 hasAuthorship W4367597570A5035293995 @default.
• W4367597570 hasAuthorship W4367597570A5038178720 @default.
• W4367597570 hasAuthorship W4367597570A5038566534 @default.
• W4367597570 hasAuthorship W4367597570A5038722866 @default.
• W4367597570 hasAuthorship W4367597570A5039626601 @default.
• W4367597570 hasAuthorship W4367597570A5042285286 @default.
• W4367597570 hasAuthorship W4367597570A5042603268 @default.
• W4367597570 hasAuthorship W4367597570A5043641903 @default.
• W4367597570 hasAuthorship W4367597570A5043968722 @default.
• W4367597570 hasAuthorship W4367597570A5044378136 @default.
• W4367597570 hasAuthorship W4367597570A5045133318 @default.
• W4367597570 hasAuthorship W4367597570A5050507557 @default.
• W4367597570 hasAuthorship W4367597570A5053280859 @default.
• W4367597570 hasAuthorship W4367597570A5057189874 @default.
• W4367597570 hasAuthorship W4367597570A5060773442 @default.
• W4367597570 hasAuthorship W4367597570A5062569735 @default.
• W4367597570 hasAuthorship W4367597570A5066263096 @default.
• W4367597570 hasAuthorship W4367597570A5066697532 @default.
• W4367597570 hasAuthorship W4367597570A5068072367 @default.
• W4367597570 hasAuthorship W4367597570A5068606243 @default.
• W4367597570 hasAuthorship W4367597570A5068784328 @default.
• W4367597570 hasAuthorship W4367597570A5068993612 @default.
• W4367597570 hasAuthorship W4367597570A5070268950 @default.
• W4367597570 hasAuthorship W4367597570A5070542745 @default.
• W4367597570 hasAuthorship W4367597570A5070802625 @default.

• next