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• W4367600681 abstract "3-Methoxyeticyclidine (3-MeO-PCE), a phencyclidine-type substance, has a higher N-methyl-D-aspartate receptor binding affinity than phencyclidine and an involvement in fatal intoxication cases. The aim of this study was to identify new biomarkers and biotransformation pathways for 3-MeO-PCE. In vitro models were established using zebrafish and human liver microsomes for analysis of the phases I and II metabolites of 3-MeO-PCE by liquid chromatography-high-resolution mass spectrometry. Urine samples of known 3-MeO-PCE consumers in forensic cases were then subjected to analysis. Overall, 14 metabolites were identified in zebrafish and human liver microsomes, allowing postulation of the following metabolic pathways: hydroxylation, O-demethylation, N-dealkylation, dehydrogenation, combination, and glucuronidation or sulfation. 3-MeO-PCE and three metabolites (M2, M3, and M6) were detected in urine. We recommended M2 (the hydroxylation product) as a potential biomarker for documenting 3-MeO-PCE intake in clinical and forensic cases." @default.
• W4367600681 created "2023-05-02" @default.
• W4367600681 creator A5005064791 @default.
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• W4367600681 date "2023-05-09" @default.
• W4367600681 modified "2023-10-17" @default.
• W4367600681 title "In vitro and in vivo metabolism of 3‐Methoxyeticyclidine in human liver microsomes, a zebrafish model, and two human urine samples based on liquid chromatography–high‐resolution mass spectrometry" @default.
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• W4367600681 doi "https://doi.org/10.1002/dta.3488" @default.
• W4367600681 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37125436" @default.
• W4367600681 hasPublicationYear "2023" @default.
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